ACARBOSE

Product: 
ACARBOSE
Formulary: 
Generic Formulary
Category: 
Diabetes
Sub Group: 
ORAL ANTIDIABETICS & RELATED DRUGS
International Brand Name: 
Glucobay,Precose, Prondose
Dosages: 
25 MG/50mg
Unit of Packing: 
Tablets
In treatment of: 
treatment of type Diabetes Mellitus
Adverse Effects: 
1 Flatulence 2.Loose stools 3.Abdominal pain 4.Diarrhoea 5.Elevated serum transaminase levels (rare)
Contraiindication: 
1 Hypersensitivity to the drug 2.Diabetic ketoacidosis 3.Cirrhosis 4.Ulcerative colitis 5.Partial intestinal obstruction 6.Chronic intestinal diseases 7.Hepatic impairment 8.Severe renal impairment 9.History of abdominal surgery 10.Hernia.
Special Precaution: 
1.Mild to moderate renal impairment 2.Monitor hepatic function tests during therapy 3.Enhance hypoglycaemic effects of sulfonylureas. Give glucose in such situations.
Interaction: 
Sucrose: Abdominal discomfort or diarrhoea. Digestive enzymes (amylase, pancreatin) and intestinal adsorbents (charcoal): Reduce efficacy of acarbose. Sulphonylureas, biguanides: Acarbose increases their efficacy. Insulin: In IDDM, insulin requirement is reduced.
Servings: 
Oral: Start with 25mg thrice daily with the 1st bite of each main meal. Increased to 50mg thrice daily; at 4 to 8 week intervals based on 1st hour postprandial glucose levels and tolerance. Then increased to 100mg thrice daily if required. Maintenance dosage: 50mg to 100mg thrice daily; depending up on the patient`s weight. Maximum dose: 200mg thrice daily.

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