Generic Formulary
Cardio Vascular System
Sub Group: 
International Brand Name: 
Sintrom and Sinthrome.
1 MG/2 mg/3 mg/4 mg
Unit of Packing: 
In treatment of: 
Mgt of Thromboembolic disorders
Adverse Effects: 
1.Haemorrhage 2.Ulceration 3.Gastrointestinal disturbances 4.Nausea 5.Vomiting 6.Dermatitis 7.Hypersensitivity reactions 8.Urticaria 9.Rash 10.Reversible alopecia 11.Liver diseases 12.Pancreatitis
1.Hypersensitivity to the drug 2.Bleeding disorders 3.Ulceration of gastrointestinal tract 4.In sub acute bacterial endocarditis 5.Severe hypertension 6.Increased capillary permeability 7.Within one day of surgery or labour 8.Renal impairment 9.Hepatic impairment.
Special Precaution: 
Use with caution in following conditions: 1.Hepatic diseases 2.Renal diseases 3.Gastrointestinal tract disorders 4.Hypertension 5.Immediately after surgery
Drugs which enhance efficacy of Acenocoumarol: NSAIDs, Amiodarone, Antibacterial agents (Cotrimoxazole, Cephalosporins, Erythromycin, Quinolone antibiotics, Chloramphenicol, Doxycycline, INH, Neomycin) Cimetidine, Allopurinol, Diuretics and Oral anticoagulants. Drugs which decrease efficacy: Bismuth bicarbonate, Rifampicin, Barbiturates, Griseofulvin, Magnesium. Oral hypoglycemic agents: Efficacy of these enhanced. Vit. K: Reverses effects
Starts with 8 to12mg on 1st day. 4 to 8mg on 2nd day. Maintenance dosage: 1 to 8mg daily.

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