International Brand Name:
1.Numbness and tingling in fingers
15.Bone marrow depression(rare)
1.Hypersensitivity to the drug
7.Long term management of non congestive chronic angle closure glaucoma
2.Sickle cell anaemia
4.Hypesensitivity to Sulfonamides
5.Chronic obstructive pulmonary disorders
8.Along with other diuretics
Amphetamine, Ephedrine, Flecainide, Pseudoephedrine, Quinidine: Potentiates effect by decreasing their renal excretion.
Digitalis: Digitals toxicity since it induces hypokalemia
Primidone: May delay absorption.
Salicylates: Salicylate toxicity due to metabolic acidosis.
Lithium: Efficacy diminished.
Sulfonamides: Aids penetration across Blood/CSF barrier.
Folic acid antagonists, Oral hypoglycaemic agents, Mercurial diuretics and Oral anticoagulants: May potentiate effect.
Lab Test: Urinary Proteins Determination - False positive results.
Glaucoma: 250mg 1 to 4 times daily
Epilepsy: Adults & Children: 8 to 30mg/kg/day in 2 to four divided doses.
Edema in heart failure: 250 to 375mg daily in the morning
Children: 5mg/kg/day orally or I.V. in the morning.
Acute mountain sickness: 250 mg 2 to 3 times daily or 500mg extended release formulation twice daily take 48 hours before ascent and continue until 48 hours after arrival at high altitude.