ACETAZOLMIDE

Product: 
ACETAZOLMIDE
Formulary: 
Generic Formulary
Category: 
Genito Urinary System
Sub Group: 
DIURETICS
International Brand Name: 
Diamox
Dosages: 
250 MG
Unit of Packing: 
Tablets
In treatment of: 
Induction of Diuresis
Adverse Effects: 
1.Numbness and tingling in fingers 2.Taste disturbances 3.Hypokalemia 4.Acidosis 5.Blurred vision 6.Headache 7.Drowsiness 8.Paresthesia 9. Fatigue 10.Abdominal discomfort 11.Nausea 12.Fever 13.Rashes 14.Allergic reactions 15.Bone marrow depression(rare) 16.Ototoxicity
Contraiindication: 
1.Hypersensitivity to the drug 2.Hyponatremia 3.Hypokalemia 4.Renal impairment 5.Hepatic impairment 6.Adrenal insufficiency 7.Long term management of non congestive chronic angle closure glaucoma 8.Hyperchloremic acidosis.
Special Precaution: 
1.Diabetes mellitus 2.Sickle cell anaemia 3.Gout 4.Hypesensitivity to Sulfonamides 5.Chronic obstructive pulmonary disorders 6.Emphysem 7.Respiratory acidosis 8.Along with other diuretics
Interaction: 
Amphetamine, Ephedrine, Flecainide, Pseudoephedrine, Quinidine: Potentiates effect by decreasing their renal excretion. Digitalis: Digitals toxicity since it induces hypokalemia Primidone: May delay absorption. Salicylates: Salicylate toxicity due to metabolic acidosis. Corticosteroids: Hypokalemia. Lithium: Efficacy diminished. Sulfonamides: Aids penetration across Blood/CSF barrier. Folic acid antagonists, Oral hypoglycaemic agents, Mercurial diuretics and Oral anticoagulants: May potentiate effect. Lab Test: Urinary Proteins Determination - False positive results.
Servings: 
Glaucoma: 250mg 1 to 4 times daily Epilepsy: Adults & Children: 8 to 30mg/kg/day in 2 to four divided doses. Edema in heart failure: 250 to 375mg daily in the morning Children: 5mg/kg/day orally or I.V. in the morning. Acute mountain sickness: 250 mg 2 to 3 times daily or 500mg extended release formulation twice daily take 48 hours before ascent and continue until 48 hours after arrival at high altitude.

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