ALLOPURINOL

Product: 
ALLOPURINOL
Formulary: 
Generic Formulary
Category: 
Musculo Skeletol Disorder
Sub Group: 
ANTIGOUT DRUGS
International Brand Name: 
Zyloprim,Allohexal, Allosig, Progout, and Zyloric,Puricos.
Dosages: 
100MG/300 mg
Unit of Packing: 
Tablets
In treatment of: 
Prevention of uric acid induced nephropathy in patients receiving high doses of anti neoplastic drugs(secondary Gount);treatment of Hyperuricaemia associated w/ Cancer Chemotherapy
Adverse Effects: 
1. Upset stomach. 2. Diarrhea. 3. Drowsiness. 4. Skin rash. 5. Painful urination. 6. Blood in the urine. 7. Irritation of the eyes. 8. Swelling of the lips or mouth. 9. Fever 10. Sore throat. 11. Chills. 12. Loss of appetite. 13. Unexpected weight loss. 14. Itching.
Contraiindication: 
1. Hypersensitivity to the drug. 2. Acute gout. 3. Hemochromatosis.
Special Precaution: 
1. Hepatic impairment. 2. Renal dysfunction. 3. Any work which require mental alertness such as driving and operating machine.
Interaction: 
ACE Inhibitors: Higher risk of hypersensitivity reactions. Oral hypoglycemic Agents: Enhanced activity. Anticoagulants: Enhanced activity. Thiopurines (Azothioprine & Mercaptopurine): Clinically significant increase in pharmacologic and toxic effects. Uricosuric Agents (Probenecid): Enhance urinary excretion of Allopurinol. Cyclophosphamide: Myelosuppressive effect of cyclophosphamide enhanced. Thiazide Derivatives: Increase in hypersensitivity reactions to Allopurinol. Ampicillin: Increase in ampicillin induced skin rash. Salicylates: Enhance urinary excretion of allopurinol.
Servings: 
Oral- Adults- Initial dose: 100 - 200 mg daily Maintenance dose: 200-800 mg daily

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