Musculo Skeletol Disorder
International Brand Name:
Zyloprim,Allohexal, Allosig, Progout, and Zyloric,Puricos.
In treatment of:
Prevention of uric acid induced nephropathy in patients receiving high doses of anti neoplastic drugs(secondary Gount);treatment of Hyperuricaemia associated w/ Cancer Chemotherapy
1. Upset stomach.
4. Skin rash.
5. Painful urination.
6. Blood in the urine.
7. Irritation of the eyes.
8. Swelling of the lips or mouth.
10. Sore throat.
12. Loss of appetite.
13. Unexpected weight loss.
1. Hypersensitivity to the drug.
2. Acute gout.
1. Hepatic impairment.
2. Renal dysfunction.
3. Any work which require mental alertness such as driving and operating machine.
ACE Inhibitors: Higher risk of hypersensitivity reactions.
Oral hypoglycemic Agents: Enhanced activity.
Anticoagulants: Enhanced activity.
Thiopurines (Azothioprine & Mercaptopurine): Clinically significant increase in pharmacologic and toxic effects.
Uricosuric Agents (Probenecid): Enhance urinary excretion of Allopurinol.
Cyclophosphamide: Myelosuppressive effect of cyclophosphamide enhanced.
Thiazide Derivatives: Increase in hypersensitivity reactions to Allopurinol.
Ampicillin: Increase in ampicillin induced skin rash.
Salicylates: Enhance urinary excretion of allopurinol.
Initial dose: 100 - 200 mg daily
Maintenance dose: 200-800 mg daily