AMIFOSTINE

Product: 
AMIFOSTINE
Formulary: 
Generic Formulary
Category: 
Neoplastics
Sub Group: 
ANTI NEOPLASTIC AGENTS
International Brand Name: 
Ethyol.
Dosages: 
500 MG
Unit of Packing: 
Vial
In treatment of: 
REDUCTION OF NEUTROPAENIA- RELATED INFECTION W// CYCLOPHOSPHAMIDE AND CISPLATIN THERAPY;REDUCTION OF CISPLATIN -INDUCED RENAL TOXITY; PREVENTION OF XEROSTOMIA DURING RADIOTHERAPY FOR HEAD AND NECK CANCER
Adverse Effects: 
1.Nausea 2 Vomiting 3.Flushing (feeling of warmth) 4.Chills ( feeling of coldness) 5.Fever 6.Dizziness 7.Drowsiness 8.Sneezing 9.Shortness of breath 10.Fainting 11.Seizures 12.Chest tightness 13.Skin rash 14.Hives 15.Swelling of the throat
Contraiindication: 
1.Hypersensitivity to the drug or any other thiol containing compound 2. Low blood pressure 3. Dehydration 4. Renal impairment 5. Hepatic impairment
Special Precaution: 
1. Cardiovascular disease 2. Cerebrovascular diseases. 3. Antihypertensive drug should be stopped 24 hrs before administration 4. Antiemetics should be administered before infusion
Interaction: 
Antihypertensives: Concomitant use of Amifostine with antihypertensive produces severe hypotension.
Servings: 
Intravenous- Adult- 740-910mg/metre square once daily over 15 min, Drug to be taken 30min before starting chemotherapy treatment Prevention of Xerostomia: 200mg / metre square once daily over 3 minutes, starting 15- 30 minutes before radiotherapy.

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