AMIODARONE

Product: 
AMIODARONE
Formulary: 
Generic Formulary
Category: 
Cardio Vascular System
Sub Group: 
ANTIARRHYTHMIC DRUGS
International Brand Name: 
Pacerone,Cordrone,Aratac,Arycor
Dosages: 
100 MG/200 mg
Unit of Packing: 
Tablets
In treatment of: 
Control of Ventricular and supraventricular arrhythmaias including those associated w/Wolff-Prakinson-white syndrome
Adverse Effects: 
Bradycardia ; Hypotension; Arrhythmia; Heart block; Heart failure; Sinus arrest; Asystole; Corneal micro deposits; Photosensitivity; Visual disturbances; Nausea; Vomiting; Constipation; Abdominal pain; Hepatic impairment; Pulmonary fibrosis; Pneumonitis ; Alveolitis Organizing pneumonia; Pleuritis; Hypothyroidism and hyperthyroidism; Pancytopenia; Neutropenia
Contraiindication: 
Hypersensitivity to the drug; Second or third degree heart block; Congestive Heart failure; Cardiogenic shock; Severe bradycardia; Severe obstructive pulmonary diseases; Electrolyte imbalance; Severe Hypotension; Myasthenia gravis; Sinus node dysfunction; Atrial conduction defects; Thyroid diseases
Special Precaution: 
Use with caution in following conditions: Hepatic impairment; Renal impairment; Heart failure; In pacemaker patients; Monitor thyroid and liver function during therapy; Along with other anti arrhythmics, beta blockers, and calcium channel blockers; Along with antivirals like Ritonavir is contraindicated and use with caution along with Amprenavir.
Interaction: 
Anticoagulants: Hypoprothrombinemic effect enhanced requiring 30% - 50% reduction in dose. Effect persists months after discontinuation of amiodarone.Beta-Blockers & Calcium Channel Antagonists ( Verapamil & Diltiazem): Additive effect.Digoxin, procainamide, Quindine, Theophyline: Increase in serum levels leading to enhanced activity of these drugs.Hydantoins: Increase in serum levels of hydantoins with decrease in levels of amiodarone.
Servings: 
0.2gm 8th hourly for one week; then 12th hourly for next week. Then reduce the dosage up to minimum effective dose.

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