APROTININ

Product: 
APROTININ
Formulary: 
Generic Formulary
Category: 
Cardio Vascular System
Sub Group: 
HAEMOSTATICS/ANTIHAEMORRHAGICS
International Brand Name: 
Dosages: 
250 MG/500 mg
Unit of Packing: 
Tablets
In treatment of: 
Treatment of Haemorrhage
Adverse Effects: 
1.Hypersensitivity reactions 2.Anaphylactic shock 3.Local thrombophlebitis 4.Dyspnoea 5.Tachycardia 6.Pallor 7.Cyanosis 8.Nausea 9.Rash 10.Skin eruptions
Contraiindication: 
Hypersensitivity to the drug
Special Precaution: 
1. First give a test dose 10 minutes prior to loading dose to access allergy to the drug. 2. If hypersensitivity reactions appear during loading dose administration stops the drug immediately.
Interaction: 
Fibrinolytic agents: May inhibit the effects of fibrinolytic agents. Heparin: May prolong activated blood clotting time. Dosage may need to be adjusted. Captopril: May block the hypotensive effect of captopril.
Servings: 
Cardio pulmonary bypass surgery: 2000,000 KIU Aprotinin loading dose, immediately after anaesthetic induction 2000,000KIU added to cardiopulmonary bypass circuit prime, and a continuous infusion of 500000 KIU during surgery until closing chest. Other wise low dose protocol is adopted which use half of full dose as effective as full dose except in anti inflammatory activity. Haemorrhage: 500000 to 1000000 KIU by slow infusion at a rate of 100000KIU/minute. Followed by 200000KIU every hour until bleeding stops.

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