ASPARAGINASE

Product: 
ASPARAGINASE
Formulary: 
Generic Formulary
Category: 
Neoplastics
Sub Group: 
ANTI NEOPLASTIC AGENTS
International Brand Name: 
Elspar
Dosages: 
5000 IU
Unit of Packing: 
Vial
In treatment of: 
INDUCTION OF REMISSION OF ADULT ACUTE LEUKAEMIA
Adverse Effects: 
Chills, Pyrexia, liver disorders. Hyperammonaemia, decrease of gfibrinogen and clotting factors, alteration in blood lipids and cholesterol, hypoalbuminaemia, Uraemia, Renal faliure (occasional) hyperglycaemia. Nausea,vomiting,Anorexia ,Wt loss CNS disturbances including depression, coma, hallucinations parkinson like su=yndrome, marked leucopaenia, Transient bone marrow depression
Contraiindication: 
Pancreatitise, Hypersensivity, Pregnancy
Special Precaution: 
Should be used after skin testing in hospital setting. Liver desease, frequently monitoring blood count, lactation
Interaction: 
Activity of metthotrexate may be replaced if L-asoparaginase is given before hand
Servings: 
Adult;1000 units/kg body wt. daily for 10 days following treatment with or without vincristine and prednisone. As monotherapy ; 200 Units/kg body wt. daily for 28 days. When administered IV, drig shoul be given over 30 min along with NS or 5% dextrose

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