ASPIRIN

Product: 
ASPIRIN
Formulary: 
Generic Formulary
Category: 
Pain & Fever
Sub Group: 
ANALGESICS & ANTIPYRETICS
International Brand Name: 
Aspirin
Dosages: 
50 MG/ 32.5 mg
Unit of Packing: 
Tablets
In treatment of: 
Treatment of Juvenile Rheumatoid artritis;releif of mild to moderate pain & Fever;Mgt of acute Rehumatic disorders eg. RA or Osteoarthritis
Adverse Effects: 
1.Nausea, 2.Vomiting, 3.Diarrhoea, 4.Gastrointestinal bleeding, 5.Abdominal distress, 6.Dyspepsia, 7.Dizziness, 8.Blurred vision, 9.Tinnitus, 10.Rash, 11.Pruritis 12.Ototoxicity
Contraiindication: 
1.Hypersensitivity to Aspirin and other NSAIDs, 2.Peptic ulcer, 3.Bleeding disorders- Haemophilia, von Willebrand`s disease 4.Chicken pox and flu like syndrome in children
Special Precaution: 
1.Hepatic impairment 2.Renal impairment 3.Cardiovascular diseases- hypertension 4.Gastrointestinal diseases 5.Hypoprothrombinemia 6.Pre existing asthma 7.Patient on anticoagulant therapy 8.Diabetes
Interaction: 
Drugs Affecting Aspirin: Activated charcoal: Decreases absorption of aspirin. Antacids Urinary alkalizers and Cortiosteroids: Decrease efficacy of aspirin. Drugs affected by aspirin: Alcohol: Risk of G.I. ulceration increases; may also prolong bleeding time. ACE inhibitors: Antihypertensive action decreased. Oral Anticoagulants : May potentiate effect. Methotrexate: Effect potentiated. Tetracycline: Efficacy decreased. Tricyclic Antidepressants - Effect potentiated. Nitroglycerin: May result in unexpected hypotension. Beta-adrenergic Blockers - Antihypertensive effect blunted. NSAIDs: May decrease serum concentration. Sulfonylureas and Exogenous Insulin: In high doses may potentiate these drugs. Valproic Acid: Potentiates effect. Spironolactone: May inhibit diuretic effect. Probenecid & Sulfinpyrazone : Antagonise uricosuric effect (In doses > 3gm/day - uricosuric effect) Lab Tests: Thyroid Function Tests: Increase in PBI Serum Uric Acid Levels: Increased by levels less than 10 mg/dl and decreased by levels> 10 mg/dl. Urine Glucose: False negative by glucose oxidase method. False positive results by reduction method. Urinary Ketones: Produce reddish colour.
Servings: 
Adult: Analgesic, antipyretic: 325 - 650mg 3 -4 times daily. Anti-inflammatory, Arthritis: 3 g / day in divided doses increases the dose if needed. Maintenance: 3.6 - 5.4 g / day in divided doses. Rheumatic fever: 4.9 - 7.8 g / day in 3 - 4 divided doses for 1- 2 weeks For prophylaxis of venous thromboembolism after total hip replacement: 650 mg twice a day started 1 day before surgery and continued for 2 weeks. For other platelet aggregation inhibitory uses: 325 to 1300 mg daily according to individual needs. For migraine: 300 - 600 mg to be taken at the first sign of migraine attack and repeated 4 - 6 hourly until suppress mild attacks. Children: Arthritis: 60 - 130 mg / kg body weight /day in divided doses Anti-inflammatory: 60 - 125 mg / kg daily in 4 - 6 hours Analgesic and Antipyretic: Adults: 1 to 2 tablets (325 to 650 mg) orally every 4 hours. Children under 12: 10 to 15 mg/kg every 6 hours, not to exceed total daily dose of 2.4 g.

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