ANALGESICS & ANTIPYRETICS
International Brand Name:
In treatment of:
Treatment of Juvenile Rheumatoid artritis;releif of mild to moderate pain & Fever;Mgt of acute Rehumatic disorders eg. RA or Osteoarthritis
1.Hypersensitivity to Aspirin and other NSAIDs,
3.Bleeding disorders- Haemophilia, von Willebrand`s disease
4.Chicken pox and flu like syndrome in children
3.Cardiovascular diseases- hypertension
6.Pre existing asthma
7.Patient on anticoagulant therapy
Drugs Affecting Aspirin:
Activated charcoal: Decreases absorption of aspirin.
Antacids Urinary alkalizers and Cortiosteroids: Decrease efficacy of aspirin.
Drugs affected by aspirin:
Alcohol: Risk of G.I. ulceration increases; may also prolong bleeding time.
ACE inhibitors: Antihypertensive action decreased.
Oral Anticoagulants : May potentiate effect.
Methotrexate: Effect potentiated.
Tetracycline: Efficacy decreased.
Tricyclic Antidepressants - Effect potentiated.
Nitroglycerin: May result in unexpected hypotension.
Beta-adrenergic Blockers - Antihypertensive effect blunted.
NSAIDs: May decrease serum concentration.
Sulfonylureas and Exogenous Insulin: In high doses may potentiate these drugs.
Valproic Acid: Potentiates effect.
Spironolactone: May inhibit diuretic effect.
Probenecid & Sulfinpyrazone : Antagonise uricosuric effect (In doses > 3gm/day - uricosuric effect)
Thyroid Function Tests: Increase in PBI
Serum Uric Acid Levels: Increased by levels less than 10 mg/dl and decreased by levels> 10 mg/dl.
Urine Glucose: False negative by glucose oxidase method. False positive results by reduction method.
Urinary Ketones: Produce reddish colour.
Analgesic, antipyretic: 325 - 650mg 3 -4 times daily.
Anti-inflammatory, Arthritis: 3 g / day in divided doses increases the dose if needed.
Maintenance: 3.6 - 5.4 g / day in divided doses.
Rheumatic fever: 4.9 - 7.8 g / day in 3 - 4 divided doses for 1- 2 weeks
For prophylaxis of venous thromboembolism after total hip replacement: 650 mg twice a day started 1 day before surgery and continued for 2 weeks.
For other platelet aggregation inhibitory uses: 325 to 1300 mg daily according to individual needs.
For migraine: 300 - 600 mg to be taken at the first sign of migraine attack and repeated 4 - 6 hourly until suppress mild attacks.
Arthritis: 60 - 130 mg / kg body weight /day in divided doses
Anti-inflammatory: 60 - 125 mg / kg daily in 4 - 6 hours
Analgesic and Antipyretic: Adults: 1 to 2 tablets (325 to 650 mg) orally every 4 hours.
Children under 12: 10 to 15 mg/kg every 6 hours, not to exceed total daily dose of 2.4 g.