Generic Formulary
Cardio Vascular System
Sub Group: 
International Brand Name: 
25 MG/50 mg/75 mg/100 mg
Unit of Packing: 
In treatment of: 
Management of Angina Pectoris
Adverse Effects: 
Heart failure; Gastrointestinal problems; Nausea; Tiredness; Sinus bradycardia; Depression; Rash; Dizziess; Fatigue; Vomiting; Diarrhoea; Bronchospasm; Fever; Leg pain; Changes in kidney function tests; Changes in liver function tests.
Hypersensitivity to the drug ;Second or third degree heart block; Heart failure; Cardiogenic shock; Sinus bradycardia
Special Precaution: 
Congestive heart failure; Hepatic impairment; Renal impairment ;The drug should be gradually withdraw with caution; Bronchospastic disorders; Diabetes mellitus; Hyper thyroidism
Alcohol, Anaesthetics, Antidepressants, Anxiolytics, Hypnotics, Cimetidine, Diuretics: Enhanced hypotensive effect.Analgesics: NSAIDs antagonise hypotensive effect.Antibacterials (Rifampicin): Reduce plasma concentration of atenolol.Antidiabetics: Enhanced hypoglycemic effect.Antihypertensives: Enhanced hypotensive effect, with clonidine there is increased severity of rebound hypertension.Calcium channel Blockers: increased risk of bradycardia and AV block with diltiazem, severe hypotension and heart failure with verapamil, nifedipine Cardiac glycosides: Increased AV block and bradycardia.Cholinergics: Effects antagonised by atenolol.Corticosteroids: Antagonism of hypotensive effect.Ergotamine: Increased peripheral vasoconstriction ;Sympathomimetics: Severe hypertension with adrenaline and noradrenaline.Lab. Tests: Interferes with Glucose or insulin tolerence tests.
Hypertension: Starts with 50mg single dose then gradually increases at weekly intervals to 100mg/day once daily based on patient`s response.Children: 1 to 1.3 mg/kg/day once daily or as two divided doses; Angina: Starts with 50mg single dose orally, and then gradually increases to 100mg/day based on patient`s response at one week intervals; Maximum dose: 200mg/dayMyocardial infarction: 5mg I.V. over 5minuts twice daily at 10minuts intervals. Then after 10minuts starts oral therapy with 50mg dose. Then 50mg at 12th hour. And increases to 100mg/day once daily or in two divided doses up to 9daysMigraine prophylaxis: 50 - 150mg / day in divided doses

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Kayem Pharma

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