BETAMETHASONE

Product: 
BETAMETHASONE
Formulary: 
Generic Formulary
Category: 
Ear Nose
Sub Group: 
AURAL PREPARATIONS
International Brand Name: 
Dosages: 
0.1%W/V
Unit of Packing: 
5ML E/E DPS
In treatment of: 
Adverse Effects: 
1.Susceptibility to infection 2.Peptic ulcer 3.Haemorrhage 4.Glycosuria 5.Hyperglycaemia 6.Osteoporosis 7.Atrophy of adrenal cortex(on prolonged therapy) 8.Suppression of adrenocorticotropic hormone 9.Cushing`s syndrome 10.Inhibition of growth in children 11.Amenorrhoea 12.Behavioral disturbances 13.Thromboembolic disorders 14.Myopathy 15.Weakness 16.Lymphocytopenia 17.Muscle wasting 18.Gastrointestinal discomfort 19.Increased appetite 20.Delayed wound healing 21.Headache 22.Euphoria 23.Insomnia 24.Seizures 25.Heart failure 26.Arrhythmias 27.Posterior sub capsular cataract 28.Glaucoma 29.Hirsutism 30.Increased intracranial pressure. Topcal: 1.Burning 2.Irritation 3.Dryness 4.Erythema 5.Folliculitis 6.Striae 7.Skin atrophy 8.tching
Contraiindication: 
1.Hypersensitivity to the drug 2.Untreated infections 3.Systemic fungal infections Topical: 1.Hypersensitivity to Betamethasone and other corticosteroids 2.Untreated bacterial, virus or fungal infections 3.Acne vulgaris 4.Peri-oral dermatitis 5.Scabies 6.Leg ulcers 7.Tuberculosis of the skin 8. Varicose ulcers 9. Skin lesions caused by infections with ring worm, fungi (e.g. Candida, Tinea) or bacteria (e.g. impetigo) 10.Discoid lupus Erythematosus
Special Precaution: 
1.Avoid sudden discontinuation of the drug 2.Use lower dosages as much as possible 3.Concurrent vaccination 4.Ocular herpes simplex 5.Primary glaucoma 6.Peptic ulcer 7.Psychosis 8.Tuberculosis 9.Epilepsy 10.Osteoporsis 11.Congestive heart failure 12.Renal impairment 13.Recent myocardial infarction 14.Heart failure 15.Diabetes mellitus 16.Hypothyroidism 17.Cirrhosis 18.Stress 19.Sepsis 20.Hypertension 21.Myasthenia gravis 22.Hepatic impairment 23.Non specific Ulcerative colitis 24.Diverticulitis 25.Recent intestinal anastomosis 26.Thromboembolic disorders 27.Avid contact of the topical dosage form with the eyes
Interaction: 
Barbiturates: Decrease efficacy of Betamethasone Carbamazepine, Primidone: Decreases efficacy. Oral contraceptives: Increase efficacy of Betamethasone. Oestrogens: Decreases efficacy of Betamethasone. Ketoconazole: Increases efficacy of Betamethasone. Rifampicin: Decreases efficacy. Betamethasone effects the actions of the following: Anticholinesterases: Efficacy antagonised in myasthenia gravis. Oral anticoagulants: Altered response. Cyclosporine: Increases efficacy leading to enhanced toxicity. Digitals glycosides: Increases toxicity associated with hypokalaemia. Isoniazid: Decreases serum levels. Salicylates: Decreases serum levels. Diuretics: Increases efficacy may cause increased hypokalaemia and increased hyperglycaemia. Non-depolarising muscle relaxants - Altered response. Somatrem: Growth promoting effect inhibited. Theophyllines: Altered response of either agent. IUCD: Contraceptive failure. Lab. Tests: a) Increases serum cholesterol levels. b) Increases urine glucose levels. c) Decreases Thyroid l 131 uptake; Decreases T3 serum levels. d) Decreases serum potassium.
Servings: 
Oral: Starts with 0.5 to 6mg/day. Reduces to minimum effective; maintenance dosage. Children: 1 to 6 years: 25 to 50% 7 to 12 years: 50 to 75% I.M. or I.V.: 4 to 20mg I.M. or as slow I.V. injection. Repeated if required; up to 4 times daily depending up on the severity of condition. Children: Administered by slow I.V. injection; <1year: 1mg 1 to 5 years: 2mg 6 to 12 years: 4mg Intra-articular or soft tissue injection: 0.5 to 9mg depending up on the severity of the condition. Topical: Betamethasone Valerate: Apply to the affected area as thin film 1 - 4 times daily depending upon the severity, skin and rate of absorption. Dermatoses of the scalp: (Betamethasone Valerate 0.12%): Small amount of foam is applied in to the scalp with gentle massage 2 times a day for up to 2 weeks. Betamethasone dipropionate: Apply to the affected area as thin film 1 -2times daily

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