Biclutamide

Product: 
Biclutamide
Formalary: 
Specialty Formalary
Category: 
Oncology
Trade Name: 
Casodex, Cosudex, Calutide, Kalumid
Packing: 
Tabs
Potency: 
50 mg
In Treatment of: 
Bicalutamide is an oral non-steroidal anti-androgen used in the treatment of prostate cancerand hirsutism
Adverse Effects: 
Adverse reactions include reproductive system and breast disorders, breast tenderness, gynaecomastia, hot flushes, gastrointestinal disorders, diarrhoea, nausea, hepatic changes (elevated levels of transaminases, jaundice), asthenia and pruritus
Contraindication: 
Bicalutamide is contraindicated in patients who have shown a hypersensitivity reaction to its use. Bicalutamide is a teratogen and must not be handled by females who are or may become pregnant. It is known to cause fatal harm
Special Precaution: 
Before taking Bicalutamide, 1. tell your doctor and pharmacist if you are allergic to bicalutamide, any other medications, or any of the ingredients in bicalutamide tablets. Ask your pharmacist for a list of the ingredients. 2. tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: alprazolam (Xanax); anticoagulants ('blood thinners') such as warfarin (Coumadin); aripiprazole (Abilify); buspirone (Buspar); calcium channel blockers such as amlodipine (Norvasc), diltiazem (Cardizem, Dilacor, Tiazac), felodipine (Plendil), nifedipine (Adalat, Procardia), nisoldipine (Sular), and verapamil (Calan, Covera, Isoptin, Verelan); chlorpheniramine; cholesterol-lowering medications (statins) such as atorvastatin (Lipitor), lovastatin (Mevacor), and simvastatin (Zocor); clarithromycin (Biaxin); cyclosporine (Neoral, Sandimmune); diazepam (Valium); erythromycin (E.E.S., E-Mycin, Erythrocin); HIV protease inhibitors such as indinavir (Crixivan), ritonavir (Norvir), and saquinavir (Invirase, Fortovase); methadone (Dolophine); midazolam (Versed); pimozide (Orap); quinidine (Quinidex, Quinaglute); quinine; sildenafil (Viagra); tacrolimus (Prograf); tamoxifen (Nolvadex); telithromycin (Ketek); trazodone (Desyrel); triazolam (Halcion); and vincristine (Vincasar). Many other medications may also interact with bicalutamide, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. 3. tell your doctor if you have or have ever had liver disease. 4. you should know that bicalutamide is only for use in men. If taken by pregnant women, bicalutamide can cause abnormalities in the fetus. Women who are or may become pregnant should not take bicalutamide. If you take bicalutamide while you are pregnant, call your doctor immediately.
Interaction: 
Budesonide Bicalutamide can increase the level of budesonide in your blood, potentially increasing your risk for side effects. This interaction is less of a problem with inhaled budesonide. If you take these medicines together, your healthcare provider may monitor you more closely and decrease your budesonide dosage if needed. Buspirone Bicalutamide can increase the level of buspirone in your blood, potentially increasing your risk for side effects. Your healthcare provider may monitor you more closely and decrease your buspirone dosage if side effects become bothersome. Calcium Channel Blockers Bicalutamide may increase the level of calcium channel blockers in the blood, increasing the risk of side effects. Check with your healthcare provider before taking these medicines together. Your healthcare provider may need to closely monitor you and adjust your calcium channel blocker dosage if necessary. Carbamazepine Bicalutamide may increase the level of carbamazepine in your blood, perhaps increasing your risk for side effects. Your healthcare provider may want to monitor the level of carbamazepine in your blood during treatment if you have to take these drugs together. Certain Antidepressants Bicalutamide may increase blood levels of the antidepressants listed above, increasing the risk of side effects. If you take these medications together, your healthcare provider may choose to lower your antidepressant dose if side effects become bothersome. Certain Antipsychotics Bicalutamide may increase blood levels of the antipsychotics listed above, potentially increasing your risk of side effects. Talk to your healthcare provider before taking these medications together. Certain Benzodiazepines Bicalutamide could increase the level of some (but not all) benzodiazepines in the blood, increasing the risk of side effects. Check with your healthcare provider before combining these drugs. Clarithromycin Bicalutamide may increase the level of clarithromycin in the blood, increasing the risk of side effects. Talk with your healthcare provider about this potential interaction before taking these drugs together. Colchicine Bicalutamide can increase the level of colchicine in your blood, increasing your risk of colchicine toxicity. Talk to your healthcare provider before combining these medications. Your healthcare provider may need to monitor you more closely and give you a lower colchicine dosage. Cyclosporine Bicalutamide could increase the level of cyclosporine in your blood, perhaps increasing your risk for side effects. Your healthcare provider may want to monitor you more closely during treatment if you have to take these medications together. Eplerenone Bicalutamide can increase the level of eplerenone in your blood, increasing your risk for side effects. Your healthcare provider will monitor you more closely if you take these medications together, and may need to adjust your eplerenone dosage. Ergot Medications Bicalutamide can increase the risk of toxicity from ergot medications. Talk to your healthcare provider before combining these drugs. Erythromycin Bicalutamide may increase the level of erythromycin in the blood, increasing the risk of side effects. Talk with your healthcare provider about this potential interaction before taking these medications together. Everolimus Bicalutamide can increase your blood levels of everolimus, increasing your risk for side effects. Talk to your healthcare provider before combining these medicines. Your healthcare provider will monitor you more closely if you take bicalutamide with everolimus and adjust your everolimus dosage if needed. Fentanyl Bicalutamide can increase fentanyl blood levels, increasing the risk for potentially serious side effects. Do not take these medications together without first talking to your healthcare provider. Your healthcare provider will need to monitor you closely during treatment, and you may need a lower fentanyl dosage. Pimecrolimus Bicalutamide has the potential to increase pimecrolimus blood levels, increasing the risk of side effects. Talk to your healthcare provider before combining these medicines. Your healthcare provider may need to monitor you more closely for pimecrolimus side effects if you take these medications together. Phosphodiesterase Type 5 Inhibitors (PDE5 Inhibitors) Bicalutamide may increase the level of PDE5 inhibitors in the blood, perhaps increasing the risk of side effects. Check with your healthcare provider before taking these medications together. A lower dose of your PDE5 inhibitor may be recommended. Ranolazine Bicalutamide may increase the level of ranolazine in your blood, increasing your risk for potentially serious side effects. Talk to your healthcare provider before taking ranolazine with bicalutamide. A lower ranolazine dosage is recommended in such cases. Salmeterol Bicalutamide could increase blood levels of salmeterol, possibly increasing the risk of side effects. Your healthcare provider will monitor you closely for salmeterol side effects, such as increased heart rate, if you take these medications together. Saxagliptin Bicalutamide may increase the level of saxagliptin in the blood, potentially increasing the risk for dangerously low blood sugar. Talk with your healthcare provider before combining these drugs. Your healthcare provider may recommend you check your blood glucose levels more often during treatment. Statins Bicalutamide may increase the level of certain statin cholesterol medications in the blood, possibly increasing the risk of side effects. Check with your healthcare provider before taking bicalutamide with a statin medication. Theophylline Bicalutamide may increase the level of theophylline in your blood. Your healthcare provider may want to monitor your theophylline levels during treatment if you take these medications together. Tolvaptan Bicalutamide may increase the level of tolvaptan in the blood, increasing your risk for side effects. Do not take these medications together without first talking to your healthcare provider. Warfarin Combining bicalutamide with warfarin may increase your risk of bleeding, especially when the two medications are first taken together. If you take bicalutamide with warfarin, your healthcare provider may need to monitor you more closely.
Dosages: 
Bicalutamide comes as a tablet to take by mouth. It is usually taken with or without food once a day, either in the morning or evening. Take bicalutamide at around the same time every day. You should begin taking bicalutamide on the same day you begin injecting the luteinizing hormone-releasing hormone. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take bicalutamide exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Bicalutamide along with the luteinizing hormone-releasing hormone may help stop the growth and spread of cancer cells but does not cure prostate cancer. Continue to take both bicalutamide and the luteinizing hormone-releasing hormone even if you feel better. Do not stop taking these medications without talking to your doctor.

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