Fertility & Antifertility Agents
International Brand Name:
1.Hypersensitivity to Bromocriptine and other ergot derivatives
5.History of psychosis
8.Concurrent antihypertensive therapy.
9.Use caution when driving vehicle operating machine or activities requiring mental alertness
Antihypertensives: Efficacy potentiated by concomitant use of bromocriptine dopamine antagonists.
Phenothiazines, butyrophenones: Decreases efficacy of these drugs.
Erythromycin: increases efficacy of bromocriptine.
Alcohol: Decreases tolerance to bromocriptine and vice-versa.
Initial dose: 1 - 1.25 mg at night with food for 1 week.
2 - 2.5 mg at night with food for 2nd week
5 mg / day in 2 divided doses for 3rd week
7.5 mg / day in 3 divided doses for 4th week.Then increase the dose by 2.5 mg daily every 3 - 14 days until sufficient therapeutic response is obtained
Maintenance dose: 10 - 40 mg/day.Maximum dose: 100 mg / day
Amenorrhea and Galactorrhea associated with hyperprolactinemia: Initial dose: 1.25 - 2.5 mg / day increase the dose by 2.5 mg daily every 3 - 7 days until sufficient therapeutic response is obtained.
Maintenance dose: 5 - 7.5 mg/day.Maximum dose: 40 mg / day
Acromegaly: Initial dose: 1.25 - 2.5 mg at night for 3 days increase the dose by 1.25 - 2.5 mg daily every 3 - 7 days until sufficient therapeutic response is obtained.Dose range: 20 - 30 mg / day in divided doses. Maximum dose: 100 mg / day
Hepatic encephalopathy: Initial dose: 1.25 mg / day increase the dose by 1.25 mg every 3 days until sufficient therapeutic response (15 mg) is obtained.
Premenstrual syndrome 5 -15 mg in 2 divided doses 10th day of menstrual cycle until onset of menstruation
Cushing`s syndrome: 1.25 - 2.5 mg 2 - 4 times daily
Suppression of established lactation: 2.5mg daily for 2 to 3 days. Subsequently increased to 2.5mg twice daily for two weeks.
Children: Not recommended