BUSULFAN

Product: 
BUSULFAN
Formulary: 
Generic Formulary
Category: 
Neoplastics
Sub Group: 
ANTI NEOPLASTIC AGENTS
International Brand Name: 
Busulfex , Myleran
Dosages: 
2 MG
Unit of Packing: 
Tablet
In treatment of: 
PALLIATIVE TREATMENT OF CHRONIC MYELOID LUKEMIA; POLYCYTHEMIA VERA;ESSENTIAL THROMBOCYTHAEMIA
Adverse Effects: 
1. Anorexia 2. Weight loss 3. Weakness 4. Hyper pigmentation 5. Amenorrha 6. Cataracts 7. Impaired fertility 8. Liver damage 9. Gynaecomastia 10. Bone marrow depression 11. Hyper pigmentation to the skin 12. Pulmonary fibrosis 13. Nausea 14. Mouth sores 15. Loss of appetite 16. Diarrhoea 17. Alopecia 18. addisons-like wasting syndrome.
Contraiindication: 
1. Hypersensitivity to the drug 2. Chronic lymphoytic leukemia 3. Acute leukemia 4."blastic" crisis of chronic myelogenous leukemia
Special Precaution: 
Cautiously used in patients with 1. Prior treatment with other myelosupressive agents 2. Seizures 3. Previous irradiation/therapy. 4. Depressed neutrophil or platelet count 5. Head trauma Monitor blood count closely. If there is any toxicity discontinue the treatment. Anticonvulsant must be used concomitantly to protect CNS from toxicities
Interaction: 
Immunisation with live viruses: Life threatening infection. Theoguanine: Nodular regenerative hyperplasia leading to oesophageal varices and abnormal liver function tests.
Servings: 
Oral- Adults- 4 to 8 mg/day for the induction of remission. 60mcg/kg for the maintenance therapy. Children-0.06 to 0.12 mg/kg for the induction of remission 60mcg/kg for the maintenance therapy. Intravenous- Adults 0.8 mg/kg i.v. every 6 hrs for 4 consecutive days for a total of 16 doses.

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