CAPTOPRIL

Product: 
CAPTOPRIL
Formulary: 
Generic Formulary
Category: 
Cardio Vascular System
Sub Group: 
ANTI HYPERTENSIVE DRUGS
International Brand Name: 
Capoten
Dosages: 
12.5 MG/25 Mg
Unit of Packing: 
Tablets
In treatment of: 
Treatment in Hyper Tension(HTN)
Adverse Effects: 
1.Cough; 2.Angioedema; 3.Hypotension; 4.Hyperkalemia; 5.Rashes; 6.Urticaria; 7.Swelling of lips, mouth, nose, and larynx; 8.Dysguesia; 9.Fetopathic in later half of pregnancy; 10.Headache
Contraiindication: 
1.Hypersensitivity to the drug; 2.Renal impairment; 3.Aortic stenosis.
Special Precaution: 
1.Renal impairment; 2.Severe autoimmune diseases; 3.Sodium depletion should be corrected before starting therapy; 4.Anaesthesia; 5.Use cautiously along with drug that affects WBC counts or immune response
Interaction: 
Antacids: Decrease efficacy of Captopril.; Indomethacin: Reduces hypotensive effect.; Digoxin: Increases plasma digoxin levels.; Potassium preparations & Postassium sparing diuretics: Hyperkalaemia and increased risk of renal failure.; Lithium: Toxicity due to increased serum concentration of Lithium.; Immunosuppressive Drugs: Increased risk of bone marrow depression.; Antidepressants, Diuretics, b-Blockers, Phenothiazines: Enhance hypotensive effect.; Morphine: Enhanced analgesic effect and respiratory depression.
Servings: 
25mg 12th hourly or 8th hourly. Increases the dose after 1 to 2 weeks to 50mg 8th hourly. If patient`s response is inadequate, a diuretic may be added. Dosage may further increases to 100mg 8th hourly based on patient`s response if required.; Maximum dose: 450mg/day; Children:0.15mg/kg/day once daily or in 3 to 6 divided doses.; Heart failure: 25mg 8th hourly. Increases to 25 to 50mg 8th hourly if required. In patients on diuretic therapy starts the therapy with an initial dosage of 6.25 to 12.5 mg 8th hourly.; Left ventricular dysfunction after myocardial infarction: Give 6.25mg orally as a single dose 3days after myocardial infarction. Then 12.5mg 8th hourly and gradually increases ; to 25mg or50mg 8th hourly.; Diabetic nephropathy: 25mg 8th hourly.

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