Generic Formulary
Sub Group: 
International Brand Name: 
150 MG/450 mg
Unit of Packing: 
In treatment of: 
Adverse Effects: 
1. Nausea 2. Vomiting 3. Lowered resistance to infection 4. Bruising or unusual bleeding 5. Anemia 6. Weakness 7. sore in mouth 8. Taste changes 9. Diarrhea 10. Loss of appetite 11. Visual changes 12. Black, tarry stools 13. Blood in urine or in stool 14. Cough or hoarseness 15. Fever 16. Chills 17. Myelosuppression 18. Mucositis 19. Dermatitis 20. Angina 21. Heart attack 22. Alopecia 23. Conjunctivitis 24. Cardiac arrhythmias 25. Hyper pigmentation 26. Breathlessness 27. Euphoria 28. Ataxia 29. Nystagmus 30. Leucopenia 31. Thrombocytopenia 32. Anaphylaxis 33. Agranulocytosis 34. Myocardial ischemia 35. Raised alkaline phosphatase level 36. Serum electrolyte level abnormalities 37. Pain 38. Asthenia 39. Central neurotoxicity 40. Peripheral neuropathies 41. Ototoxicity 42. Blood urea level elevations 43. Embolism 44. Cerebrovascular accidents 45. Mucositis
1. Hypersensitivity to the drug, platinum containing compounds and mannitol 2. Severe bone marrow depression 3. Bleeding
Special Precaution: 
1. Diminished renal function 2. Amino glycosides neurotoxicity 3. Liver function impairment
Phenytoin : Serum concentration may be decreased resulting in loss of therapeutic effect.
Intravenous Adult- 300-600mg/metre square i.v.infusion every 3-4 weeks For brain tumors in children- 175mg/metre square weekly for 4 weeks, with a 2 weeks recovery period between courses

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