Carboplatin

Product: 
Carboplatin
Formalary: 
Specialty Formalary
Category: 
Oncology
Trade Name: 
Paraplatin
Packing: 
Injection
Potency: 
150mg/15ml, 450mg/45ml, 500mg/50ml
In Treatment of: 
"Carboplatin is an anticancer drug (""antineoplastic"" or ""cytotoxic"") chemotherapy drug. Carboplatin is classified as an ""alkylating agent."" Carboplatin is used to treat ovarian cancer. Carboplatin is also used for other types of cancer, including lung, head and neck, endometrial, esophageal, bladder, breast, and cervical; central nervous system or germ cell tumors; osteogenic sarcoma; and as preparation for a stem cell or bone marrow transplant. Note: If a drug has been approved for one use, physicians may elect to use this same drug for other problems if they believe it may be helpful.
Adverse Effects: 
Most people do not experience all of the side effects listed.Side effects are often predictable in terms of their onset and duration.Side effects are almost always reversible and will go away after treatment is complete.There are many options to help minimize or prevent side effects. There is no relationship between the presence or severity of side effects and the effectiveness of Carboplatin. The side effects of Carboplatin and their severity depend on how much of Carboplatin is given. In other words, high doses may produce more severe side effects). The following side effects are common (occurring in greater than 30%) for patients taking Carboplatin: 1. Low blood counts (including red blood cells, white blood cells and platelets) Nadir: Meaning low point, nadir is the point in time between chemotherapy cycles in which you experience low blood counts. 2. Onset: None reported Nadir: 21 days Recovery: 28 days 3. Nausea and vomiting usually occurring within 24 hours of treatment 4. Taste changes 5. Hair loss 6. Weakness 7. Blood test abnormalities: Abnormal magnesium level These are less common (occurring in 10-29%) side effects for patients receiving Carboplatin: 1. Burning sensation at the injection site 2. Abdominal pain 3. Diarrhea 4. Constipation 5. Mouth sores 6. Infection 7. Peripheral neuropathy: Although uncommon, a serious side effect of decreased sensation and paresthesia (numbness and tingling of the extremities) may be noted. Sensory loss, numbness and tingling, and difficulty in walking may last for at least as long as therapy is continued. These side effects may become progressively more severe with continued treatment, and your doctor may decide to decrease your dose. 8. Central neurotoxicity: Infrequent but patients over age 65 are at increased risk. Symptoms include dizziness, confusion, visual changes, ringing in the ears. 9. Nephrotoxicity (see kidney problems): More frequent when Carboplatin is given in high doses or to people with kidney problems. 10. Hearing loss (ototoxicity) - loss of high pitched sounds. 11. Abnormal blood electrolyte levels (sodium, potassium, calcium). 12. Abnormal blood liver enzymes (SGOT, Alkaline phosphatase) (see liver problems). 13. Cardiovascular events. Although infrequent, heart failure, blood clots and strokes have been reported with Carboplatin use. Less than 1% were life-threatening. 14. Allergic reaction may occur. It would occur during the actual transfusion. This may include itching, rash, shortness of breath or dizziness (especially in patients who have received cisplatin). 15. Not all side effects are listed above, some that are rare (occurring in less than 10% of patients) are not listed here. However, you should always inform your health care provider if you experience any unusual symptoms.
Contraindication: 
Carboplatin Injection is contraindicated in patients with a history of severe allergic reactions to cisplatin or other platinum-containing compounds. Carboplatin Injection should not be employed in patients with severe bone marrow depression or significant bleeding
Special Precaution: 
Contact your health care provider immediately, day or night, if you should experience any of the following symptoms: Fever of 100.4(F (38(C) or higher, or chills (possible signs of infection). 1. Difficulty breathing or shortness of breath. 2. Chest pain. The following symptoms require medical attention, but are not an emergency. Contact your health care provider within 24 hours of noticing any of the following: 1. Unusual bleeding or bruising 2. Black or tarry stools, or blood in your stools or urine 3. Diarrhea (4-6 episodes in a 24-hour period) 4. Nausea (interferes with ability to eat and unrelieved with prescribed medications). 5. Vomiting (vomiting more than 4-5 times in a 24-hour period) 6. Severe abdominal pain 7. Lip or mouth sores (painful redness, swelling or ulcers) 8. Extreme fatigue (unable to carry on self-care activities) 9. Muscle cramps or twitching 10. Change in hearing 11. Dizziness, confusion or visual changes Always inform your health care provider if you experience any unusual symptoms. Carboplatin Precautions:  Before starting Carboplatin treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc. Do not take aspirin, products containing aspirin unless your doctor specifically permits this.  Carboplatin may be inadvisable if you have a history of severe allergic reaction to cisplatin, Carboplatin, other platinum-containing formulations or mannitol.  Do not receive any kind of immunization or vaccination without your doctor's approval while taking Carboplatin.  Decreased sensation, numbness and tingling in fingers and toes may become progressively worse with repeated doses of Carboplatin. It is important to report this to your doctor.  Inform your health care professional if you are pregnant or may be pregnant prior to starting this treatment. Pregnancy category D (Carboplatin may be hazardous to the fetus. Women who are pregnant or become pregnant must be advised of the potential hazard to the fetus).  For both men and women: Do not conceive a child (get pregnant) while taking Carboplatin. Barrier methods of contraception, such as condoms, are recommended. Discuss with your doctor when you may safely become pregnant or conceive a child after therapy.  Do not breast feed while taking Carboplatin. Carboplatin Self Care Tips:  Drink at least two to three quarts of fluid every 24 hours, unless you are instructed otherwise.  You may be at risk of infection so try to avoid crowds or people with colds, and report fever or any other signs of infection immediately to your health care provider.  Wash your hands often.  To help treat/prevent mouth sores, use a soft toothbrush, and rinse three times a day with 1/2 to 1 teaspoon of baking soda and/or 1/2 to 1 teaspoon of salt mixed with 8 ounces of water.  Use an electric razor and a soft toothbrush to minimize bleeding.  Avoid contact sports or activities that could cause injury.  To reduce nausea, take anti-nausea medications as prescribed by your doctor, and eat small, frequent meals.  Avoid sun exposure. Wear SPF 15 (or higher) sunblock and protective clothing.  In general, drinking alcoholic beverages should be kept to a minimum or avoided completely. You should discuss this with your doctor.  Get plenty of rest.  Maintain good nutrition.  If you experience symptoms or side effects, be sure to discuss them with your health care team. They can prescribe medications and/or offer other suggestions that are effective in managing such problems. Monitoring and Testing While Taking Carboplatin: You will be monitored regularly by your doctor while you are taking Carboplatin. Tests will include complete blood counts, electrolytes, kidney function tests and liver enzymes. Because drug toxicity is seen as numbness and tingling of fingers and toes, a periodic physical examination, which includes a check of your reflexes, is necessary to detect the need for decreased dosages.
Interaction: 
The renal effects of nephrotoxic compounds may be potentiated by carboplatin.
Dosages: 
Carboplatin is usually given by infusion into a vein (intravenous, IV). Carboplatin can also be given intra-peritoneal, directly into the peritoneal cavity in the abdomen. The amount of Carboplatin you receive depends on many factors, including your height and weight, your general health or other health problems, and how your body responds to it. Your doctor will determine your dose and schedule.

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