CEFAZOLIN

Product: 
CEFAZOLIN
Formulary: 
Generic Formulary
Category: 
Infections & Infestations
Sub Group: 
ANTIBACTERIALS
International Brand Name: 
Cefazoline,Cephazolin, Anuf,Cefacidal, Cefamezin,Cefina, Elzogram,Faxilen, Gomaxin, Kefazol,Kefol,Kefzol, Kefzolon
Dosages: 
1GM INJ; 250 mg;500mg
Unit of Packing: 
Inj
In treatment of: 
Treatment of Billiary tract infections,Staphylococcal Endocarditis and peritonitis
Adverse Effects: 
1.Pain after I.M. injection & thrombophlebitis after I.V. injection 2.Rashes 3.Allergic manifestation 4.Vaginitis 5.Pruritis 6.Candidiasis 4.Nephrotoxicity 5.Pseudo membranous colitis 6.Glossitis 7.Elevated liver enzymes 8.Nausea 9.Vomiting
Contraiindication: 
1.Hpersensitivity to cephalosporins 2.Aong with other nephrotoxic drugs 3.Along with oral anticoagulants 4.Pseudo membranous colitis
Special Precaution: 
1.Renal impairment 2.Patient allergic to penicillins 3.Neuromuscular disorders
Interaction: 
Aminoglycosides (Gentamycin, Tobramycin): Nephrotoxicity of aminoglycosides potentiated. Oral anticoagulants: Hypoprothrombinaemic effect potentiated, bleeding complications may occur. Bacteriostatic agents like Chloramphenicol: Decrease efficacy of Cefazolin. Probenecid: Slows tubular excretion and this enhances efficacy. Frusemide & Ethacrynic Acid: Potentiate nephrotoxicity of Cefazolin. Lab. test: Urine Glucose: False positive with Benedicts solution and Fehlings solution. Direct Coomb
Servings: 
Adults: 500mg to 1gm I.M. or I.V. three times daily or four times daily. Maximum adult dose: Up to 12gm/day Children: 25 to 50 mg/kg/day I.M or I.V. three times daily or four times daily. Maximum child dose: 100mg/kg/day

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