CHLORAMPHENICOL

Product: 
CHLORAMPHENICOL
Formulary: 
Generic Formulary
Category: 
Ear Nose
Sub Group: 
AURAL PREPARATIONS
International Brand Name: 
Alficetyn,Amphicol, Biomicin,Chlornitromycin,Chloromycetin,Chlosig, Fenicol,Chloramex
Dosages: 
5% W/V+1% W/V
Unit of Packing: 
5ML E/E DPS
In treatment of: 
Treatment of Otitis Externa
Adverse Effects: 
1.Bone marrow depression 2.Aplastic anaemia 3.Agranulocytosis 4.Thrombocytopenia 5.Gray baby syndrome 6.Super infections 7.Rashes & Hypersensitivity reactions 8.Angioedema 9.Nausea 10.Vomiting 11.Diarrhoea 12.Pain at injection site
Contraiindication: 
1.Hypersensitivity to chloramphenicol 2.As a prophylactic agent in infections & In the treatment of trivial infections
Special Precaution: 
1.Renal impairment 2.Hepatic impairment 3.Concurrent use of other drugs which cause bone marrow suppression 4.Porphyria 5.G6PD deficiency
Interaction: 
Dicoumarol, Phenytoin, Phenobarbital, Tolbutamide & Chlorpropamide: Efficacy enhanced when Chloramphenicol administered concomitantly since it inhibits the metabolism of these drugs. Cyclophosphamide: Efficacy reduced. Acetaminophen: Efficacy of Chloramphenicol potentiated leading to toxicity. Iron salts and Vit. B12: Haematologic response decreased. Penicillin: Decreases efficacy of penicillin and increases serum concenteration of chloramphenicol. Rifampicin: Reduces serum chloramphenicol levels (hepatic enzyme induction). Tricyclic Anti-Depressants: Blood levels and adverse effects increased. Mannitol & Hydrochlorothiazide: Increases renal excretion of chloramphenicol.
Servings: 
Adults: 0.25 to 0.5gm four times daily or 50mg/kg/day In severe infections & Meningitis: 100mg/kg/day four times daily Maximum total dose: 28gm Children: 25 to 50mg/kgm/day four times daily In severe infections: 100mg/kg/day four times daily

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