International Brand Name:
Alficetyn, Amphicol,Biomicin, Chloramex,Vernacetin, Medicom,Chlosig, Cipro
In treatment of:
Treatment of Eye infection
1.Bone marrow depression
5.Gray baby syndrome
7.Rashes & Hypersensitivity reactions
12.Pain at injection site
1.Hypersensitivity to chloramphenicol
2.As a prophylactic agent in infections & In the treatment of trivial infections
3.Concurrent use of other drugs which cause bone marrow suppression
Dicoumarol, Phenytoin, Phenobarbital, Tolbutamide & Chlorpropamide: Efficacy enhanced when Chloramphenicol administered concomitantly since it inhibits the metabolism of these drugs.
Cyclophosphamide: Efficacy reduced.
Acetaminophen: Efficacy of Chloramphenicol potentiated leading to toxicity.
Iron salts and Vit. B12: Haematologic response decreased.
Penicillin: Decreases efficacy of penicillin and increases serum concenteration of chloramphenicol.
Rifampicin: Reduces serum chloramphenicol levels (hepatic enzyme induction).
Tricyclic Anti-Depressants: Blood levels and adverse effects increased.
Mannitol & Hydrochlorothiazide: Increases renal excretion of chloramphenicol.
0.25 to 0.5gm four times daily or 50mg/kg/day
In severe infections & Meningitis: 100mg/kg/day four times daily
Maximum total dose: 28gm
25 to 50mg/kgm/day four times daily
In severe infections: 100mg/kg/day four times daily