Musculo Skeletol Disorder
NASAIDS(Non Sterodial Anti Inflamatory Drugs)
International Brand Name:
In treatment of:
Discoid & systemic Lupus Erythematosus
1.Hypersensitivity to Chloroquine and other 4 Amino quinolines
3.Patients with G -6-PD deficiency
4.Preexisting retinal damage
Antacids: Reduced absorption.
Cholinergics: Effects of Neostigmine and pyridostigmine antagonized.
Cimetidine: Inhibits metabolism raising plasma levels.
Pyrimethamine, Sulphadoxine: May cause Steven-Johnson`s Syndrome.
Quinacrine: Increased toxicity with quinacrine.
Phenylbutazone: Predisposes to dermatitis.
Ampicillin: Bioavailability of ampicillin reduced.
Adult: Initial dose: 600 mg base; after 6 hours 300 mg base; third and forth dose (300 mg base) is administered after 24 and 48 hours of initial dose.
Rheumatoid arthritis: 250 mg once daily at night
Extraintestinal amoebiasis: 600 mg once daily for 2 days followed by 300 mg once daily for 14 - 21 days
Discoid Lupus Erythematosus: 250 mg once daily at night
Children: Initial dose: 10mg /kg body weight; after 6 hours 5mg /kg body weight; third and forth dose (5mg /kg body weight) is administered after 24 and 48 hours of initial dose.