Generic Formulary
Musculo Skeletol Disorder
Sub Group: 
NASAIDS(Non Sterodial Anti Inflamatory Drugs)
International Brand Name: 
250 MG
Unit of Packing: 
In treatment of: 
Discoid & systemic Lupus Erythematosus
Adverse Effects: 
1.Nausea 2.Vomiting 3.Diarrhoea 4.Abdominal cramps 5.Pruritis 6.Headache 7.Dizziness 8.Hypotension 9.Visual disturbances
1.Hypersensitivity to Chloroquine and other 4 Amino quinolines 2.Porphyria 3.Retinal damage
Special Precaution: 
Hepatic dysfunction 1.Renal impairment 2.Epilepsy 3.Patients with G -6-PD deficiency 4.Preexisting retinal damage 5.Haematological disorder 6.Gastrointestinal disorder
Antacids: Reduced absorption. Cholinergics: Effects of Neostigmine and pyridostigmine antagonized. Cimetidine: Inhibits metabolism raising plasma levels. Pyrimethamine, Sulphadoxine: May cause Steven-Johnson`s Syndrome. Quinacrine: Increased toxicity with quinacrine. Phenylbutazone: Predisposes to dermatitis. Ampicillin: Bioavailability of ampicillin reduced.
Adult: Initial dose: 600 mg base; after 6 hours 300 mg base; third and forth dose (300 mg base) is administered after 24 and 48 hours of initial dose. Rheumatoid arthritis: 250 mg once daily at night Extraintestinal amoebiasis: 600 mg once daily for 2 days followed by 300 mg once daily for 14 - 21 days Discoid Lupus Erythematosus: 250 mg once daily at night Children: Initial dose: 10mg /kg body weight; after 6 hours 5mg /kg body weight; third and forth dose (5mg /kg body weight) is administered after 24 and 48 hours of initial dose.

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