CHLORPROPAMIDE

Product: 
CHLORPROPAMIDE
Formulary: 
Generic Formulary
Category: 
Diabetes
Sub Group: 
ORAL ANTIDIABETICS & RELATED DRUGS
International Brand Name: 
Dosages: 
Unit of Packing: 
Tablets
In treatment of: 
treatment of type Diabetes Mellitus
Adverse Effects: 
1.Hypoglycaemia 2.Nausea 3.Vomiting 4.Diarrhoea 5.Constipation 6.Headache 7.Presthesia 8.Weight gain 9.Hypersensitivity reactions 10.Rashes 11.Photosensitivity 12.Purpura 13.Transient leucopenia 14.Agranulocytosis 15.Cholestatic jaundice 16.Dilutional hyponatraemia 17.Alcohol intolerance.
Contraiindication: 
1.Hypersensitivity to the drug 2.Type1 diabetes mellitus 3.Diabetes that can be adequately controlled by diet 4.Infection 5.Stress 6.Hepatitis 7.Cirrhosis 8.Alcoholics 9.Cardiac disease 10.Renal impairment
Special Precaution: 
1.Hepatic impairment 2.Cardiac failure 3.Respiratory failure 4.Ischaemic vascular disease 5.Pancreatitis 6.Porphyria 7.Malnourished individuals
Interaction: 
Alcohol: Dilsulfiram like reaction - flushing of face and neck region. Androgens, Anticoagulants, Chloramphenicol, Clofibrate, Fenfluramine, Fluconazole, Gemfibrozil, Histamine H2 antagonists, Magnesium salts, Methyldopa, MAOIs, Phenylbutazone, Probenecid, Salicylates, Sulfinpyrazone, Sulfonamides, TCAs, Urinary acidifiers: Enhance the hypoglycemic effect of chlorpropamide due to various mechanisms. Beta-Blockers, Cholestyramine, Diazoxide, Hydantoins, Rifampicin, Thiazide diuretics & Urinary alkalizers: Decrease hypoglycemic effect of chlorpropamide due to various mechanisms. Charcoal: Reduces the absorption of chlorpropamide leading to decrease in efficacy or toxicity. Digitalis Glycosides: Increase serum levels.
Servings: 
Oral: Starts with 100 to 250mg once daily with breakfast or in divided doses; if gastrointestinal disturbances occur. Adjust the dosage by increments of 50 to 125mg daily at every 3 to 5 days. Maximum dose: 500mg/day

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