CHLORTALIDONE

Product: 
CHLORTALIDONE
Formulary: 
Generic Formulary
Category: 
Cardio Vascular System
Sub Group: 
DIURETICS
International Brand Name: 
Clorpres
Dosages: 
12.5 MG/25 Mg
Unit of Packing: 
Tablets
In treatment of: 
Treatment of Oedema associated w/ heart failure
Adverse Effects: 
1.Dizziness 2.Nausea 3.Diarrhoea 4.Vomiting 5.Dry mouth 6.Weakness 7.Hypokalaemia 8.Hyponatraemia 9.Hyperuricaemia 10.Elevated levels of glucose, calcium, and lipids 11.Altered liver function tests 12.Altered kidney function tests 13.Gastro intestinal disturbances 14.Impotence 15.Visual impairment 16.Electrolyte imbalance 17.Jaundice 18.Ototoxicity
Contraiindication: 
1.Hypersensitivity to the drug 2.Hypokalaemia 3.Hyperuricaemia 4.Renal impairment 5.Hepatic impairment 6.Anuria 7.Hyponatraemia 8.Hypercalcaemia 9.Addison`s disease 10.Chronic obstructive pulmonary diseases
Special Precaution: 
1.Gout 2.Hepatic diseases 3.Renal impairment 4.Fluid and electrolyte imbalance 5.Hyperlipidaemia 6.Severe heart failure 7.Cirrhosis 8.Diabetes mellitus 9.Ventricular extra systoles
Interaction: 
Cholestyramine & Colestipol : decrease absorption of chlorthalidone. Diazoxide : Additive action may cause hyperglycemia, hyperuricaemia and hypotension. Digitalis : Diuretic induced hypokalaemia may precipitate digitalis toxicity. Lithium : Chlorthalidone potentiates therapeutic and toxic effects by decreasing its renal excretion. Frusemide :Synergy leading to profound diuresis and greater than predicted electrolyte loss. Non-depolarizing muscle relaxants : Diuretic induced hypokalaemia enhances efficacy. Sulfonylureas : Efficacy decreased due to chlorthalidone induced glucose intolerance. Chlorpropamide : Hypokalemia. Propantheline : Bioavailability of chlorthalidone increased. Metoclopramide : Bioavailability of chlorthalidone decreased. NSAID
Servings: 
Adult: Hypertension: 25mg daily. Increased to 50mg if required; depending up on the patient`s response. Oedema: Starts with 50mg. Increased to 100 to 200mg on alternate days; if required. Maintenance dosage: 25 to 50mg daily or on alternate days. Children: Hypertension:2mg/kg/day; thrice a week.

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