CICLOSPORIN

Product: 
CICLOSPORIN
Formulary: 
Generic Formulary
Category: 
Immunosuppressants
Sub Group: 
IMMUNOSUPPRESANTS
International Brand Name: 
Cyclosporine
Dosages: 
25 mg/ 50 mg/100mg
Unit of Packing: 
Sg-Capsule
In treatment of: 
Prophylaxis of Graft rejection in organ Transplantation
Adverse Effects: 
1. Seizures 2. Tremor 3. Hypertension 4. Sinusitis 5. Gum hyperplasia 6. Nausea 7. Vomiting 8. Diarrhea 9. Nephrotoxicity 10. Leucopenia 11. Thrombocytopenia 12. Hepatotoxicity 13. Anaphylaxis 14. Flushing 15. Hirsuitism 16. Hemolytic anemia 17. Increased susceptibility to infections 18. Hyperkalemia 19. Fluid retention 20. Gynecomastia
Contraiindication: 
1. Hypersensitivity to the drug or its ingredient 2. Malignant neoplasm
Special Precaution: 
1. Renal impairment 2. Hepatic dysfunction 3. Hyperurecemia 4. Anaphylaxis 5. History of allergic diseases 6. Epilepsy 7. Monitor patients BP, serum electrolyte, renal and hepatic function regularly.
Interaction: 
Servings: 
Oral- Adult- Organ transplantation:10-15mg/kg/day, starting at 4-12 hrs before procedure and continued for 1-2 weeks, maintenance dose is 2-6mg/kg Corneal transplantation.15 mg/ kg /day for 4-12hrs before transplantation. Continue this after surgery for 1-2 weeks Children: Corneal transplantation.15 mg/ kg /day for 4-12hrs before transplantation. Continue this after surgery for 1-2 weeks Intravenous- Bone marrow transplantation: 3-5mg/kg/day for 2 weeks, maintenance dose is 12.5mg/kg

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