CISPLATIN

Product: 
CISPLATIN
Formulary: 
Generic Formulary
Category: 
Neoplastics
Sub Group: 
ANTI NEOPLASTIC AGENTS
International Brand Name: 
Platino
Dosages: 
10 mg/ 50 mg
Unit of Packing: 
Inj-20ml
In treatment of: 
Treatment of Mestatic Ovarian & Bladder Cancer;Mestatic Testicular Tumours
Adverse Effects: 
1. Nausea 2. Vomiting 3. Lowered resistance to infection 4. Bruising or unusual bleeding 5. Anemia 6. Weakness 7. Sore in mouth 8. Taste changes 9. Diarrhea 10. Loss of appetite 11. Visual changes 12. Black, tarry stools 13. Blood in urine or in stool 14. Cough or hoarseness 15. Fever 16. Chills 17. Lower back or side pain 18. Painful or difficult urination 19. Pinpoint red spot on skin 20. Slurred speech 21. Swelling on leg or lower leg 22. Shortness of breath 23. Pulmonary fibrosis 24. Hepatotoxicity 25. Nephrotoxicity 26. Stomatitis 27. Disorientation 28. Lethargy 29. Ataxia 30. Thrombocytopenia 31. Leucopenia 32. Bone marrow suppression 33. Raynaud`s syndrome 34. Hyperkalemia 35. Hypomagnesaemia 36. Hemolysis 37. Sterility 38. Teratogenesis 39. Ototoxicity 40. Peripheral neuropathy 41. Papilloedema 42. Hypocalcaemia 43. Hyperurecemia 44. Seizures 45. Optic neuritis
Contraiindication: 
1. Hypersensitivity to the drug or other platinum compounds 2. Severe renal disease 3. Hearing impairment 4. Myelosuppression 5. Peripheral neuropathy
Special Precaution: 
Monitor renal, neurological and auditory functions of patient regularly. Used with caution in patients with : 1. Renal disorder 2. Kidney disease 3. Hypocalcaemia 4. Hypomagnesaemia
Interaction: 
inoglycosides: Nephrotoxicity potentiated by aminoglycosides. Loop diuretics: Additive ototoxic effect. Phenytoin: Plasma levels reduced by cisplatin. Cytotoxic drugs: Increased toxicity when combined with other cytotoxic drugs. Still ideal drug to combine since it causes very little myelosuppression. 5-Fluorouracil & Etoposide: Synergy. Radioprotecting Agent WR 2721: Efficacy enhanced and toxicity reduced.
Servings: 
Intravenous- Adult- For metastatic testicular cancer - 20mg /metre square /day for 5 days. Repeat the treatment every 3 weeks for 3 cycles or more. For ovarian cancer -75 to100mg/metre square . Repeat every 4 weeks OR 50mg/metre square every 3 weeks. Bladder cancer-50 to70mg/metre square once every 3 to 4 weeks. Head and neck cancer-80 to 120mg/metre square every 3 weeks. Cervical cancer-50mg/metre square once every 3 weeks. Lung cancer-70 to 120mg/metre square once every 3 to 6 weeks. Children- Brain tumour-60mg/metre square for 2 days every 3 to 4 weeks. Osteogenic sarcoma or neuroblastoma-90mg/metre square every 3 weeks.

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Kayem Pharma

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