International Brand Name:
6.Difficulty in micturition
10. Dryness of mouth
21.Loss of libido
1.Hypersensitivity to Clomipramine
4.Severe liver disease.
7.Angle closure glaucoma
8.History of urine retention
11.Slowly withdraw the drug with caution
12.Patient should be cautioned against driving vehicle, operating machine and activities requiring mental alertness or judgment
Anticholinergics: Enhanced effect of anticholinergics may occur.
Barbiturates: Serum level of imipramine decreased; additive respiratory depressant effect.
Clonidine: Hypertensive crisis.
Dicoumarol: Increase in anticoagulation effects.
Disulfiram: Acute organic brain syndrome.
Fluoxetine & Haloperidol: Potentiate action of Clomipramine.
Levodopa: Its bioavailability is reduced, hypertensive episodes.
MAOIs, Furazolidone: Seizures, sweating, coma, hyperexcitability, hyperthermia, tachycardia, mydriasis, confusion, DIC (Disseminated Intravascular Coagulation) and death.
Oral Contraceptives and Phenothiazines: Increase plasma levels of Clomipramine.
Smoking: Increases metabolic bio-transformation.
Alcohol: Sedative effect of alcohol potentiated.
Depression: Initial dose: 10 mg at night. Dose can be gradually increased to 150 mg / day at night or in 3 - 4 divided doses.
Maintenance dose: 30 - 50 mg daily
Maximum dose: 250 mg / day
Obsessive compulsive disorder:
Initial dose: 25 mg at night. Dose can be gradually increased to 150 mg / day at night or in 3 - 4 divided doses.