Generic Formulary
Central Nervous System
Sub Group: 
Anti Depressants
International Brand Name: 
10 MG/25 MG/50MG/75 MG
Unit of Packing: 
In treatment of: 
Treatment of depression
Adverse Effects: 
1.Drowsiness 2.Dizziness 3 Nausea 4.Vomiting 5.Blurred vision 6.Difficulty in micturition 7.Tachycardia 8.Hypotension 9.Arrhythmia 10. Dryness of mouth 11.Constipation 12.Confusion 13.Headache 14.Sedation 15.Agranulocytosis 16.Urticaria 17.Rash 18.Jaundice 19.Anorexia 20. Impotence 21.Loss of libido 22.Galactorrhea 23.Gynecomastia
1.Hypersensitivity to Clomipramine 2.Myocardial infarction 3.Epilepsy 4.Severe liver disease.
Special Precaution: 
1.Hepatic impairment 2.Cardiac arrhythmia 3.Myocardial infarction 4.Renal impairment 5.Heart failure 6.Strokes 7.Angle closure glaucoma 8.History of urine retention 9.Hyperthyroidism 10.Alcoholics 11.Slowly withdraw the drug with caution 12.Patient should be cautioned against driving vehicle, operating machine and activities requiring mental alertness or judgment 13.Tachycardia
Anticholinergics: Enhanced effect of anticholinergics may occur. Barbiturates: Serum level of imipramine decreased; additive respiratory depressant effect. Clonidine: Hypertensive crisis. Dicoumarol: Increase in anticoagulation effects. Disulfiram: Acute organic brain syndrome. Fluoxetine & Haloperidol: Potentiate action of Clomipramine. Levodopa: Its bioavailability is reduced, hypertensive episodes. MAOIs, Furazolidone: Seizures, sweating, coma, hyperexcitability, hyperthermia, tachycardia, mydriasis, confusion, DIC (Disseminated Intravascular Coagulation) and death. Oral Contraceptives and Phenothiazines: Increase plasma levels of Clomipramine. Smoking: Increases metabolic bio-transformation. Alcohol: Sedative effect of alcohol potentiated.
Adult: Depression: Initial dose: 10 mg at night. Dose can be gradually increased to 150 mg / day at night or in 3 - 4 divided doses. Maintenance dose: 30 - 50 mg daily Maximum dose: 250 mg / day Obsessive compulsive disorder: Initial dose: 25 mg at night. Dose can be gradually increased to 150 mg / day at night or in 3 - 4 divided doses.

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