CYCLOPHOSPHAMIDE

Product: 
CYCLOPHOSPHAMIDE
Formulary: 
Generic Formulary
Category: 
Neoplastics
Sub Group: 
ANTI NEOPLASTIC AGENTS
International Brand Name: 
Endoxan , Cytoxan, Neosar , Procytox
Dosages: 
1 GM/ 200mg/500mg
Unit of Packing: 
Vial
In treatment of: 
CONDITIONING REGIMEN FOR BONE MARROW TRANSPLANTATION
Adverse Effects: 
1. Cardiotoxicity 2. Anorexia 3. Vomiting 4. Nausea 5. Stomatitis 6. Mucositis 7. Hepatotoxicity 8. Hemorrhagic cystitis 9. Leucopenia 10. Thrombocytopenia 11. Anemia 12. Pulmonary fibrosis 13. Reversible alopecia 14. Anaphylaxis 15. Secondary malignant disease 16. Nausea 17. Darkening of the skin and nails. 18. Facial flushing 19. Dizziness 20. Runny eyes and nose 21. Dizziness
Contraiindication: 
1. Hypersensitivity to this drug 2. Bone marrow suppression
Special Precaution: 
1. Impaired renal function 2. Hepatic failure 3. Leucopenia 4. Thrombocytopenia 5. Dependant on chemotherapy and radiation therapy
Interaction: 
Chloramphenicol: Decreased efficacy of cyclophosphamide due to increase in half-life and decrease in metabolite concentration, increased risk of bone marrow toxicity. Thiazide diuretics: Increased efficacy, anti-neoplastic induced leukopoenia may be prolonged. Anticoagulants: Increase in anticoagulant effect. Digoxin: Decreased serum levels of digoxin. Doxorubicin: Doxorubicin induced cardiac toxicity potentiated. Succinylcholine: Neuromuscular blockade prolonged. Allopurinol: Increased risk of bone marrow toxicity. Phenobarbitone: Increased metabolism and leukopenic activity. Myelotoxic drugs, Radiotherapy: Serious toxicity.
Servings: 
Oral- Adults - 60mg/kg daily for 2 to 4 days. Intravenous- Adults-2 to 6 mg/kg weekly as a single low-dose regimen. 10 to 15 mg/kg weekly as a single moderate-dose regimen. 20 to 40 mg/kg as a single high- dose regimen every 10 to 20 days

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