CYTARABINE

Product: 
CYTARABINE
Formulary: 
Generic Formulary
Category: 
Neoplastics
Sub Group: 
ANTI NEOPLASTIC AGENTS
International Brand Name: 
Cytosar-U.
Dosages: 
1 GM/100 mg/500 mg
Unit of Packing: 
Vial
In treatment of: 
TREATMENT OF ACUTE LUKAEMIA& REFRACTORY DISEASE
Adverse Effects: 
1. Neurotoxicity 2. Malaise 3. Dizziness 4. Headache 5. Conjunctivitis 6. Renal dysfunction 7. Nausea 8. Vomiting 9. Leucopenia 10. Thrombocytopenia 11. Diarrhea 12. Anorexia 13. Anal ulcer 14. Abdominal pain 15. Hepatotoxicity 16. Jaundice 17. Myalgia 18. Bone pain 19. Rash 20. Pruritis 21. Flu like syndrome 22. Hyperurecemia 23. Thrombophlebitis 24. Edema 25. Anaphylaxis 26. Bloody stool 27. Hyper pigmentation 28. Alopecia 29. Sore throat 30. Oesophagitis 31. Rhabdomyolysis 32. Reticulocytopenia
Contraiindication: 
1. Contraindicated in patient with hypersensitivity to the drug
Special Precaution: 
1. Hepatic impairment 2. Renal dysfunction 3. Bone marrow depression 4. Severe infections 5. Monitor patients WBC and platelet count periodically 6. Assess patient`s renal and hepatic function periodically
Interaction: 
Radiotherapy & other myelotoxic drugs: Bone marrow depression potentiated. Digoxin: Decreased serum levels of digoxin. Effect seen even several days after stopping therapy. Gentamicin & Flurocytosine: Efficacy of both decreased.
Servings: 
Intravenous- Adult- For the treatment of leukemia: 75-150mg/metre square /day or 5mg/kg/day for 5 days For the treatment of refractory disease: 3mg/metre square every 12 hrs for up to 6days Intrathecal- Adult- 10 - 30 mg/metre square every 2 to 4 days.

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