DACARBAZINE

Product: 
DACARBAZINE
Formulary: 
Generic Formulary
Category: 
Neoplastics
Sub Group: 
ANTI NEOPLASTIC AGENTS
International Brand Name: 
DTIC, DTIC-Dome
Dosages: 
100 MG/ 200 mg/500 mg
Unit of Packing: 
Vial
In treatment of: 
TREATMENT OF MESTATIC MALIGNANT MELANOMA
Adverse Effects: 
1. Nausea 2. Vomiting 3. Lowered resistance to infection 4. Bruising or unusual bleeding 5. Anemia 6. Weakness 7. Sore in mouth 8. Taste changes 9. Diarrhea 10. Loss of appetite 11. Visual changes 12. Black, tarry stools 13. Blood in urine or in stool 14. Cough or hoarseness 15. Fever 16. Chills 17. Lower back or side pain 18. Painful or difficult urination 19. Pinpoint red spot on skin 20. Slurred speech 21. Swelling on leg or lower leg 22. Shortness of breath 23. Pulmonary fibrosis 24. Hepatotoxicity 25. Nephrotoxicity 26. Stomatitis 27. Disorientation 28. Lethargy 29. Ataxia 30. Thrombocytopenia 31. Leucopenia 32. Bone marrow suppression 33. Alopecia 34. Urticaria 35. Photosensitivity 36. Hepatic necrosis 37. Renal impairment 38. Flu like syndrome 39. Myalgia
Contraiindication: 
1. Hypersensitivity to the drug 2. Bone marrow suppression
Special Precaution: 
1. Impaired bone marrow function 2. Hepatic impairment 3. Renal impairment 4. Monitor haematological functions regularly 5. Restricted the food intake before the drug administration.
Interaction: 
Servings: 
Intravenous- Adult- Metastatic malignant melanoma: 2-4.5mg/kg/day for 10 days, repeat the treatment every 4 weeks OR 250mg/metre square /day for 5 days, repeated every 3 weeks. Hodgkin`s disease-150mg/metre square for 5 days, repeat every 4 weeks OR 375mg/metre square on day 1of a combination regimen, repeat every 15 days

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