DANAZOL

Product: 
DANAZOL
Formulary: 
Generic Formulary
Category: 
Endocrine System
Sub Group: 
GONADOL HORMONE & RELATED DRUGS
International Brand Name: 
Danocrine
Dosages: 
50 MG/100mg/200mg
Unit of Packing: 
Tablets
In treatment of: 
Treatment of benegin breast disorders
Adverse Effects: 
1.Amenorrhoea 2.Loss of libido in men 3.Hot flushes in women 4.Night sweats 5.Muscle cramps 6.Nausea 7.Gastrointestinal upset 8.Abnormal liver enzyme tests 9.Cholestatic jaundice 10.Androgenic effects in women 11.Acne 12.Hirsutism 13.Deepening of voice 14.Oedem 15.Weight gain 16.Muscle spasm 17.Headache 18.Sleep disorders.
Contraiindication: 
1.Abnormal genital bleeding of unknown etiology 2.Porphyria 3.Cardiac oedema 4.Renal impairment 5.Hepatic impairment 6.Pelvic infection 7.Undiagnosed uterine or ovarian masses 8.Jaundice on oral contraceptive therapy.
Special Precaution: 
1.Seizures 2.Migraine 3.Diabetes 4.Hypertension 5.Long term therapy 6.Monitor hepatic function tests
Interaction: 
Insulin: Increase in insulin requirement in diabetics due to insulin resistance. Warfarin: Potentiation of anti-coagulant effect. Oral contraceptives: Interfere with danazol action. Anti-epileptics: May require adjustment in their doses. Lab tests: Glucose Tolerance. Tests: Decreased glucose tolerance. Liver function Tests: Elevated values reported.
Servings: 
Oral: Mild endometriosis: Starts with 100 to 200mg 12th hourly up to 6months. Adjust the dosage based on patient`s response. Moderate to severe endometriosis: 400mg 12th hourly up to 6months. Fibrocystic breast disease, Gynaecomastia: 100 to 400mg/day as two divided doses for 2 to 6months. Menorrhagia: 200mg/day for 3 months. Hereditary angioedema: 200mg 12th hourly to 8th hourly until therapeutic effect is obtained. Then reduce the dosage to half at 1 to 3 month intervals.

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