International Brand Name:
In treatment of:
Treatment of Endometriosis,preoperative thinning of the Endometrium
2.Loss of libido in men
3.Hot flushes in women
8.Abnormal liver enzyme tests
10.Androgenic effects in women
13.Deepening of voice
1.Abnormal genital bleeding of unknown etiology
7.Undiagnosed uterine or ovarian masses
8.Jaundice on oral contraceptive therapy.
5.Long term therapy
6.Monitor hepatic function tests
Insulin: Increase in insulin requirement in diabetics due to insulin resistance.
Warfarin: Potentiation of anti-coagulant effect.
Oral contraceptives: Interfere with danazol action.
Anti-epileptics: May require adjustment in their doses.
Lab tests: Glucose Tolerance.
Tests: Decreased glucose tolerance.
Liver function Tests: Elevated values reported.
Mild endometriosis: Starts with 100 to 200mg 12th hourly up to 6months. Adjust the dosage based on patient`s response.
Moderate to severe endometriosis: 400mg 12th hourly up to 6months.
Fibrocystic breast disease, Gynaecomastia:
100 to 400mg/day as two divided doses for 2 to 6months.
Menorrhagia: 200mg/day for 3 months.
Hereditary angioedema: 200mg 12th hourly to 8th hourly until therapeutic effect is obtained. Then reduce the dosage to half at 1 to 3 month intervals.