DAPSONE

Product: 
DAPSONE
Formulary: 
Generic Formulary
Category: 
Infections & Infestations
Sub Group: 
ANTILEPROTICS
International Brand Name: 
Meloprim
Dosages: 
25MG/ 50 mg/100 mg
Unit of Packing: 
Tablets
In treatment of: 
Treatment of multibacilliary Leprosy; and treatment of Paucibacillary Leprosy
Adverse Effects: 
1.Nausea 2.Anorexia 3.Rashes 4.Hypermelanosis 5.Photo toxicity 6.Exfoliative dermatitis 7.Anaemia 8.Peripheral neuropathy 9.Nephrotic syndrome 10.Psychological changes 11.Haemolysis 12.Methaemoglobinaemia 13.Vomiting
Contraiindication: 
1.Hypersensitivity to the drug 2.In G6PD deficient individuals 3.Porphyria 4.In severe anemia
Special Precaution: 
1.Renal impairment 2.Hepatic impairment 3.Cardiovascular disorders 4.Anaemia 5.Starts with a lower dose & increases gradually
Interaction: 
Rifampicin: Lowers dapsone levels even to ten fold by accelerating plasma clearance. Folic acid antagonists: Increase the likelihood of hematologic reactions. Para-aminobenzoic acid: Antagonises the effect of dapsone. Activated charcoal: Decreases Gl absorption and enterohepatic recycling of dapsone. Probenecid: Reduces urinary excretion of dapsone, increasing plasma concentration.
Servings: 
Adults: 50 to 100mg orally Multibacillary leprosy: 100 mg daily with Rifampin& Clofazimine for12 months. Paucibacillary leprosy: 100mg daily with Rifampin for 6 months Dermatitis herpetiformis: 50mg/day increase up to 400mg for full control & then reduce dose Acne: 100mg/day Children: 50mg/day orally or 1 to 2mg/kg/day Children: Adjusted dosage + Rifampin + Clofazimine for 12 months for multibacillary leprosy & adjusted dosage + Rifampin for 6 months for Paucibacillary leprosy

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