Infections & Infestations
International Brand Name:
In treatment of:
Treatment of multibacilliary Leprosy; and treatment of Paucibacillary Leprosy
1.Hypersensitivity to the drug
2.In G6PD deficient individuals
4.In severe anemia
5.Starts with a lower dose & increases gradually
Rifampicin: Lowers dapsone levels even to ten fold by accelerating plasma clearance.
Folic acid antagonists: Increase the likelihood of hematologic reactions.
Para-aminobenzoic acid: Antagonises the effect of dapsone.
Activated charcoal: Decreases Gl absorption and enterohepatic recycling of dapsone.
Probenecid: Reduces urinary excretion of dapsone, increasing plasma concentration.
Adults: 50 to 100mg orally
Multibacillary leprosy: 100 mg daily with Rifampin& Clofazimine for12 months.
Paucibacillary leprosy: 100mg daily with Rifampin for 6 months
Dermatitis herpetiformis: 50mg/day increase up to 400mg for full control & then reduce dose
Children: 50mg/day orally or 1 to 2mg/kg/day
Children: Adjusted dosage + Rifampin + Clofazimine for 12 months for multibacillary leprosy & adjusted dosage + Rifampin for 6 months for Paucibacillary leprosy