Generic Formulary
Infections & Infestations
Sub Group: 
International Brand Name: 
25MG/ 50 mg/100 mg
Unit of Packing: 
In treatment of: 
Treatment of multibacilliary Leprosy; and treatment of Paucibacillary Leprosy
Adverse Effects: 
1.Nausea 2.Anorexia 3.Rashes 4.Hypermelanosis 5.Photo toxicity 6.Exfoliative dermatitis 7.Anaemia 8.Peripheral neuropathy 9.Nephrotic syndrome 10.Psychological changes 11.Haemolysis 12.Methaemoglobinaemia 13.Vomiting
1.Hypersensitivity to the drug 2.In G6PD deficient individuals 3.Porphyria 4.In severe anemia
Special Precaution: 
1.Renal impairment 2.Hepatic impairment 3.Cardiovascular disorders 4.Anaemia 5.Starts with a lower dose & increases gradually
Rifampicin: Lowers dapsone levels even to ten fold by accelerating plasma clearance. Folic acid antagonists: Increase the likelihood of hematologic reactions. Para-aminobenzoic acid: Antagonises the effect of dapsone. Activated charcoal: Decreases Gl absorption and enterohepatic recycling of dapsone. Probenecid: Reduces urinary excretion of dapsone, increasing plasma concentration.
Adults: 50 to 100mg orally Multibacillary leprosy: 100 mg daily with Rifampin& Clofazimine for12 months. Paucibacillary leprosy: 100mg daily with Rifampin for 6 months Dermatitis herpetiformis: 50mg/day increase up to 400mg for full control & then reduce dose Acne: 100mg/day Children: 50mg/day orally or 1 to 2mg/kg/day Children: Adjusted dosage + Rifampin + Clofazimine for 12 months for multibacillary leprosy & adjusted dosage + Rifampin for 6 months for Paucibacillary leprosy

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