DAUNORUBICIN

Product: 
DAUNORUBICIN
Formulary: 
Generic Formulary
Category: 
Neoplastics
Sub Group: 
ANTI NEOPLASTIC AGENTS
International Brand Name: 
DaunoXome
Dosages: 
20 mg
Unit of Packing: 
Vial
In treatment of: 
TREATMENT OF ACUTE LUKAEMIA
Adverse Effects: 
1. Nausea 2. Vomiting 3. Lowered resistance to infection 4. Bruising or unusual bleeding 5. Anemia 6. Weakness 7. Sore in mouth 8. Taste changes 9. Diarrhea 10. Loss of appetite 11. Visual changes 12. Black, tarry stools 13. Blood in urine or in stool 14. Cough or hoarseness 15. Fever 16. Chills 17. Lower back or side pain 18. Painful or difficult urination 19. Pinpoint red 20. Slurred speech 21. Swelling on leg or lower leg 22. Shortness of breath 23. Pulmonary fibrosis 24. Spot on skin 25. Alopecia 26. Seizures 27. Insomnia 28. Cardiomyopathy 29. Cardiac arrest 30. Pulmonary hypertension 31. Neutropenia 32. Injection site inflammation 33. Influenza like syndrome 34. Depression
Contraiindication: 
1. Hypersensitivity to the drug 2. Cardiac diseases 3. Bone marrow suppression 4. Recent radiotherapy and chemotherapy 5. Recent immunizations
Special Precaution: 
1. Hepatic impairment 2. Renal diseases
Interaction: 
Immunisation with live vaccines not recommended as daunorubicin is immunosupressant. Radiation: Enhanced radiation induced toxicity of myocardium, mucosa, skin & liver. Heparin in solution, aluminium and dexamethasone: Incompatible with these drugs.
Servings: 
Intravenous- Adults- 40mg/m2 over 60 minutes once every 2 weeks 30 to 60 mg/m2 once daily for 3 -6 consecutive days, starting on day 1.It is repeated every 3 to 4weeks. Children- 25-45mg/m2/day for 3 to 4 weeks

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