Infections & Infestations
International Brand Name:
Democlocyclene, Declomycin,Declosatin, Ledermycin
In treatment of:
Treatment of suceptible infections caused by gm+ve and Gm -ve Bacteria;treatment of Atypical Pneumonia
16.Elevated liver enzymes
17.Discoloration of teeth
18.Retardation of bone growth
3.Avoid use together with milk & milk products, Antacids, Cations, Vitamins, Products which contain divalent or trivalent cations
4.Potentiation of action of anticoagulants; so avoid use together.
Antacids (aluminium, calcium, zinc, magnesium), Iron salts, Bismuth salts: Impair absorption of demeclocycline thus reducing its efficacy.
Anticoagulants: Increases the hypothrombinemic effects of anti-coagulants.
Cimetidine: Decreases GI absorption leading to decreased efficacy of demeclocyline.
Digoxin: Increases serum levels leading to digoxin toxicity.
Methoxyflurane: Nephrotoxic effects of both increased.
Oral contraceptives: Breakthrough bleeding or pregnancy due to decreased efficacy.
Penicillins: Efficacy reduced.
Food: Dairy products decrease efficacy of demeclocycline.
Lab Tests: Bacteriosuppressive levels of demeclocycline persist in both urine and blood interfering with culture studies.
Adults: 300mg orally twice daily or 150mg orally four times daily
In severe infections: 300 mg orally thrice daily
Children (above 8years of age): 8 to12mg/kg/day 2 - 4times daily