DEMECLOCYCLINE

Product: 
DEMECLOCYCLINE
Formulary: 
Generic Formulary
Category: 
Infections & Infestations
Sub Group: 
ANTIBACTERIALS
International Brand Name: 
Democlocyclene, Declomycin,Declosatin, Ledermycin
Dosages: 
150 MG; 300 mg
Unit of Packing: 
Tablets
In treatment of: 
Treatment of suceptible infections caused by gm+ve and Gm -ve Bacteria;treatment of Atypical Pneumonia
Adverse Effects: 
1.Headache 2.Dizziness 3.Intracranial 4.Hypertension 5.Nausea 6.Vomiting 7.Diarrhoea 8.Epigastric distress 9.Pancreatitis 10.Super infection 11.Skin rashes 12.Hypersensitivity reactions 13.Pericarditis 14.Neutropenia 15.Thrombocytopenia 16.Elevated liver enzymes 17.Discoloration of teeth 18.Retardation of bone growth 13.Esophageal ulceration
Contraiindication: 
1.Hypersensitive individuals
Special Precaution: 
1.Renal impairment: 2.Hepatic impairment: 3.Avoid use together with milk & milk products, Antacids, Cations, Vitamins, Products which contain divalent or trivalent cations 4.Potentiation of action of anticoagulants; so avoid use together. 5.Diabetes mellitus 6.Hyperthyroidism 7.Hypertensions
Interaction: 
Antacids (aluminium, calcium, zinc, magnesium), Iron salts, Bismuth salts: Impair absorption of demeclocycline thus reducing its efficacy. Anticoagulants: Increases the hypothrombinemic effects of anti-coagulants. Cimetidine: Decreases GI absorption leading to decreased efficacy of demeclocyline. Digoxin: Increases serum levels leading to digoxin toxicity. Methoxyflurane: Nephrotoxic effects of both increased. Oral contraceptives: Breakthrough bleeding or pregnancy due to decreased efficacy. Penicillins: Efficacy reduced. Food: Dairy products decrease efficacy of demeclocycline. Lab Tests: Bacteriosuppressive levels of demeclocycline persist in both urine and blood interfering with culture studies.
Servings: 
Adults: 300mg orally twice daily or 150mg orally four times daily In severe infections: 300 mg orally thrice daily Children (above 8years of age): 8 to12mg/kg/day 2 - 4times daily

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