DESMOPRESSIN

Product: 
DESMOPRESSIN
Formulary: 
Generic Formulary
Category: 
Endocrine System
Sub Group: 
VASOPRESSIN ANALOGUES
International Brand Name: 
DDAVP, Stimate,Minirin
Dosages: 
1MCG/ML
Unit of Packing: 
Vial/5 MD
In treatment of: 
Control of Cranial Diabetes insipidus;mgt of primary Nocturnal Enuresis
Adverse Effects: 
1.Headache 2.Hyponatraemia 3.Fluid retention 4 Stomach pain 5.Nausea 6.Vomiting 7.Abdominal cramps 8.Epistaxis 9.Sore throat 10.Allergic manifestations 11.Urticaria 12.Anaphylaxis.
Contraiindication: 
1.Hypersensitivity to the drug 2.Type IIB Von Willebrand`s disease 3.Cardiac insufficiency 4.Conditions treated with diuretics
Special Precaution: 
1 Renal impairment 2.Hypertension 3 Cardiovascular disease 4.Cystic fibrosis 5.Fluid and electrolyte imbalance.
Interaction: 
Analgesics: Effect of desmopressin potentiated by indomethacin.
Servings: 
Diagnosis of diabetes insipidus: 20mcg Adult: Intranasal: Diagnosis of diabetes insipidus: 20mcg Diabetes insipidus treatment: 10 to 40mcg in 1 to 3 divided doses. Use the lowest effective dose and separately adjust morning and evening doses for adequate diurnal rhythm of water turn over. Primary nocturnal enuresis: 20mcg as two to four metered sprays intranasally at bed time. Adjust the dosage based on patient`s response.Maximum dose: 40mcg/day. Kidney function test:40mcg after bladder emptying Oral: Diabetes insipidus: 100 to 200mcg thrice daily. Children: 5 to 20mcg at bed time. Primary nocturnal enuresis: children above 6 years:20mcg as two to four metered sprays intranasally at bed time. Adjust the dosage based on patient`s response.Maximum dose: 40mcg/day. Kidney function test: 20mcg after bladder emptying Children below 1 year old: 10mcg Reduce fluid intake to half for further two feeds Nocturia associated with multiple sclerosis: 10 to 20mcg at bed time.

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