DEXAMETHASONE

Product: 
DEXAMETHASONE
Formulary: 
Generic Formulary
Category: 
Skin
Sub Group: 
TOPICAL STEROID PREPARATION
International Brand Name: 
Dexacor,Dexasone, Decadron, Hexadrol
Dosages: 
0.01% W/W
Unit of Packing: 
Tube
In treatment of: 
SKIN DISORDER
Adverse Effects: 
1.Susceptibility to infection 2.Peptic ulcer 3.Haemorrhage 4.Glycosuria 5.Hyperglycaemia 6.Osteoporosis 7.Atrophy of adrenal cortex(on prolonged therapy) 8.Suppression of adrenocorticotropic hormone 9.Cushing`s syndrome 10.Inhibition of growth in children 11.Amenorrhoea 12.Behavioral disturbances 13.Thromoembolic disorders 14.Myopahy 15.Weaknss 16.Lymphocytopenia 17.Muscle wasting 18.Gastrointestinal discomfort 19.Increased appetite 20.Delayed wound healing 21.Headache 22.Euphoria 23.Insomnia 24.Seizures 25.Heart failure 26.Arrhythmias 27.Posterior sub capsular cataract 28.Glaucoma 29.Hirsutism 30.Increased intracranial pressure Eye preparation: 1.Burning 2.Redness 3.Stinging in the eye 4.Blurred vision
Contraiindication: 
1.Hypersensitivity to the drug 2.Psychosis 3.Tuberculosis 4.Untreated infections 5.Systemic fungal infections 6.Osteoporosis 7.Congestive heart failure 8.Renal impairment
Special Precaution: 
1.Avoid sudden discontinuation of the drug 2.Use lower dosages as much as possible 3.Ocular herpes simplex 4.Primary glaucoma 5.Peptic ulcer 6.Epilepsy 7.Recent myocardial infarction 8.Heart failure 9.Diabetes mellitus 10.Hypothyroidism 11.Cirrhosis 12.Stress 13.Sepsis 14.Hypertension 15.Myasthenia gravis 16.Hepatic impairment 17.Non specific Ulcerative colitis 18.Diverticulitis 19.Recent intestinal anastomosis 20.Thromboembolic disorders Eye preparation: 1.Cataracts 2.Contact lens wearer 3.Diabetes 4.Glaucoma
Interaction: 
ENDOCRINE SYSTEM: Barbiturates: Decreases efficacy of dexamethasone. Carbamazepine, Primidone: Decreases efficacy. Oral contraceptives: Increases efficacy of dexamethasone. Ephedrine: Decrease efficacy of dexamethasone. Oestrogens: Decrease efficacy of dexamethasone Hydantoins: Decrease efficacy of dexamethasone Ketoconazole: Increase efficacy of dexamethasone Rifampicin: Decreases efficacy. Dexamethasone effects the actions of the following: Anticholinesterases: Efficacy antagonised in myasthenia gravis. Oral anticoagulants: Altered response. Cyclosporine: Increased cyclosporine efficacy leading to enhanced toxicity. Digitalis glycosides: Increased toxicity associated with hypokalaemia. Isoniazid: Decreased serum levels of isoniazid. Salicylates: Decreased serum levels of salicylates. Diuretics: Increase efficacy may cause increased hypokalaemia and increased hyperglycemia. Non-depolarising muscle relaxants: Altered response. Theophyllines: Altered response of either agent. IUCDs: contraceptive failure. Lab. Tests: a) Increases serum cholesterol levels. Increases urine glucose levels. Decreases Thyroid I131 uptake. Decreases T3 serum levels. Decreases serum potassium. Brain Scan: Dexamethasone alters result of brain scan due to decreased uptake of radioactive material.
Servings: 
Oral: 0.5 to 10mg/day depending up on the severity of the condition. I.M. or I.V.: 0.5 to 20mg/day I.M. or as slow I.V. injection depending up on the severity of the condition; repeated as required up to 80mg/day. Antiemetic: 4 to 8 mg by mouth immediately before moderately-emetogenic chemotherapy and 20 mg by intravenous injection for more severely emetogenic chemotherapy. Children: 100mcg to 500mcg/kg/day

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