Generic Formulary
Genito Urinary System
Sub Group: 
International Brand Name: 
0.5 MG
Unit of Packing: 
Pre-filled Syringes
In treatment of: 
Cervical priming,induction and augmentation of Labour
Adverse Effects: 
1. Forceful uterine contractions 2. Haemorrhage 3. Vaginal irritations 4. Nausea 5. Vomiting 6. Dirrhoea 7. Amniotic fluid embolism 8. Post operative infections 9. Abdominal pain 10. Headache 11. Dizziness
1. Hypersensitivity to prostaglandins 2. Pelvic inflammatory disease 3. Ruptured membranes 4. Malpresentation 5. Cephalopelvic disproportion 6. Grand multiparity 7. Suspected foetal compromise 8. Undiagnosed vaginal bleeding 9. Previous uterine surgery 10. Situations where vaginal delivery is not indicated as in herpes genitalis
Special Precaution: 
1. Pelvic infections 2. Cardiac disease 3. Renal impairment 4. Hepatic impairment 5. Lung disease 6. Asthma 7. Altered blood pressure 8. Diabetes 9. Seizure disorder 11. Infections in the vaginal area 12. Womb scarring
Oxytocics: Enhanced efficacy of oxytocics leading to uterine rupture. Antiprogestins (Epostane, mefipristone): Enhance efficacy of Dinoprostone. NSAIDs: Use the combination cautiously. Oestrogen: Enhances cervical ripening and potentiates efficacy of Dinoprostone when used for therapeutic abortion.
Cervical gel: 0.5mg Dinoprostone in to the cervical canal. Vaginal gel: 1mg Dinoprostone in to the vagina. Apply another 1 to 2mg; 6hours after the first dose as required. Vaginal suppository :( for uterus to contract to abort a pregnancy): 10 to 20mg in to vagina every 3 to 5 hours as required. Oral: 0.5mg hourly till induction up to the maximum dose of 1.5mg/hour.

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