DISOPYRAMIDE

Product: 
DISOPYRAMIDE
Formulary: 
Generic Formulary
Category: 
Cardio Vascular System
Sub Group: 
ANTIARRHYTHMIC DRUGS
International Brand Name: 
Norpace,Rythmodan
Dosages: 
100 MG/150 mg
Unit of Packing: 
Tablets
In treatment of: 
Mgt of supraventricular &ventricular arrhythmias
Adverse Effects: 
Dry mouth ; Constipation; Urinary retention; Blurred vision; Hypotension; Heart failure; Heart block; Oedema; Arrhythmias; Shortness of breath; Chest pain; Dizziness; Agitation; Fatigue; Weakness ; Syncope; Cholestatic jaundice; Rashes; Pruritus; Muscle pain
Contraiindication: 
Hypersensitivity to the drug ; Cardiogenic shock ; Complete Second or third degree Heart block; Sinus node diseases; Cardiomyopathy ; Hypotensive state; Prostate hypertrophy; Cardiac failure
Special Precaution: 
Renal impairment ; Hepatic impairment; Congestive heart failure; Conduction abnormalities; Myasthenia gravis; Glaucoma; Digitalis intoxication; History of embolism; Sinus Bradycardia; Muscle weakness
Interaction: 
Anti-arrhythmics: Avoid other antiarrhythmics except in life threatening conditions. Beta Blockers & Verapamil: Adverse negative chronotopic and inotropic effects potentiated. Erythromycin: Efficacy of disopyramide enhanced leading to arrhythmias and increased QT intervals. Quinidine: Increased disopyramide serum levels leading to toxicity and decreased quinidine levels resulting in reduced efficacy. Rifampicin: Decreases serum levels of disopyramide. Digoxin: Potentiates inhibitory effect on conduction system produced by digitalis.Hydantoin: Efficacy of disopyramide reduced upto several days after withdrawal of hydantoin. Anticholinergic effects may be enhanced.
Servings: 
Initially 200 to 300mg loading dose; proportionate to bodyweight. Then 100 to 150mg; four times daily. Or 300mg twice daily. Maximum dose: 800mg in three to four divided doses. Children (age 12 to 18): 6 to15mg/kg/day. Children (age 4 to 12): 10 to15mg/kg/day. Children (age 1 to 4): 10 to 20mg/kg/day. Children (younger than 1): 10 to 30mg/kg/day.

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