DISULFIRAM

Product: 
DISULFIRAM
Formulary: 
Generic Formulary
Category: 
Poisonning and Drug Dependance
Sub Group: 
ALCOHOLISM
International Brand Name: 
Antabuse and Antabus
Dosages: 
250 mg
Unit of Packing: 
Tablets- Sustained Release
In treatment of: 
Adjunctive treatment of Chronic Alcoholism
Adverse Effects: 
1.Headache 2.Drowsiness 3.Depresion 4.Neuritis 5.Rashes 6.Metallic taste 7.Nervousness 8.Malaise 9.Abdominal upset
Contraiindication: 
1.Hypersensitivity to Disulfiram 2.Myocardial disease 3.Coronary occlusion
Special Precaution: 
1.Diabetes mellitus 2.Renal impairment 3.Hypothyroidism 4.Seizure disorder 5.Cerebral damage 6.Nephritis 7.Hepatic cirrhosis 8.Patient on Phenytoin therapy
Interaction: 
Alcohol: Severe alcohol intolerance reaction-intense flushing of face and neck accompanied by sweating, palpitation, tachycardia, dyspnoea, dizziness, headache, hypertension initially and then hypotension, gastrointestinal disturbances, exhaustion, sleep, convulsion, cardiopulmonary arrest. Benzodiazepines: Increases CNS depression of those benzodiazapines metabolised by oxidation. Caffeine: Cardiovascular & CNS stimulation effects of caffeine enhanced. Hydantoins: Increases serum hydantoin levels resulting in toxicity. Isoniazid: Unsteady gait and marked changes in behaviour. Metronidazole: Acute toxic psychosis or confusional state. Phenothiazine: Hypotensive effect potentiated. TCAs: Acute organic brain syndrome. Warfarin: Increase in anticoagulant effect.
Servings: 
Adult: Initial dose: 1g / day then gradually decrease the dose by 0.25g every day up to 0.25 g. Maintenance dose: 0.125-0.5 mg/day for 2 weeks or until permanent self control is obtained.

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