DOCETAXEL

Product: 
DOCETAXEL
Formulary: 
Generic Formulary
Category: 
Neoplastics
Sub Group: 
ANTI NEOPLASTIC AGENTS
International Brand Name: 
Zoladex
Dosages: 
20 mg/80 mg
Unit of Packing: 
Vial
In treatment of: 
Treatment of Breast Cancer as a single agent after failure of previous
Adverse Effects: 
1. Nausea 2. Vomiting 3. Lowered resistance to infection 4. Bruising or unusual bleeding 5. Anemia 6. Weakness 7. Sore in mouth 8. Taste changes 9. Diarrhea 10. Loss of appetite 11. Visual changes 12. Black, tarry stools 13. Blood in urine or in stool 14. Cough or hoarseness 15. Fever 16. Chills 17. Lower back or side pain 18. Painful or difficult urination 19. Pinpoint red spot on skin 20. Slurred speech 21. Swelling on leg or lower leg 22. Shortness of breath 23. Bloody vomiting 24. Thinned or brittle hair 25. Mouth blistering 26. Thrombocytopenia 27. Leucopenia 28. Erythematosus patches 29. Eruptions 30. Scleroderma 31. Onycholysis 32. Alopecia 33. Asthenia 34. Arthralgia 35. Myalgia 36. Mucositis 37. Tachycardia 38. Atrial flutter 39. Dysrrrythmia 40. Hypertension 41. Heart failure 42. Stomatitis 43. Increase of hepatic transaminase, bilirubin and alkaline phosphatase level
Contraiindication: 
1. Hyper sensitivity to the drug or other ingredient of the drug. 2. Severe bone marrow depression 3. Severe liver diseases
Special Precaution: 
1.Hepatic impairment 2.Monitor blood functions, liver functions and blood counts regularly
Interaction: 
Servings: 
Intravenous- Adult- Breast cancer: 60 to 100mg/metre square over 1 hr every 3 weeks Lung cancer: 100mg/metre square over 1 hr every 3 weeks In combination therapy :75-100mg/metre square over 1 hr every 3 weeks

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