DOMPERODONE+PARACETAMOL

Product: 
DOMPERODONE+PARACETAMOL
Formulary: 
Generic Formulary
Category: 
Pain & Fever
Sub Group: 
ANTIMIGRAINE DRUGS
International Brand Name: 
Dosages: 
10MG +500 MG
Unit of Packing: 
Tablets
In treatment of: 
Domperidone is a dopamine antagonist which works to prevent vomiting(symptom of migrane).Domperidone is given w// Paracetamol,an analgesic,for relief of migrane
Adverse Effects: 
1.Diarrhoea 2.Dry mouth 3.Galactorrhoea 4.Gynaecomastia 5.Skin rash 6.Abdominal discomfort 7.Dystonic reactions
Contraiindication: 
1.Hypersensitivity to Domperidone 2.Prolactin releasing pituitary tumour(prolactinoma) 3.Gastrointestinal obstruction
Special Precaution: 
1.Hepatic impairment 2.Renal impairment
Interaction: 
Digoxin: Oral dose of digoxin needs to be reduced. Aspirin, Paracetamol & Oral Diazepam: Increases absorption of these agents. Anticholinergic agents: Antagonize the effects of domperidone. Phenothiazines: CNS depression enhanced by domperidone. Antimuscarinic agents and opioids: Antagonize GI effects of domperidone. Suxamethonium: Neuromuscular blockade enhanced by domperidone.
Servings: 
Adults: 30 - 40 mg / day in 3 - 4 divided doses 30 minutes before meals and at bed time if required. After 2 weeks dose can be increased to 60 - 80 mg / day if needed. Migraine: 20 mg by mouth may be taken up to every 4 hours with Paracetamol, as required up to a maximum of 4 doses in 24 hours. Children: 300 mcg / kg body weight 3 - 4 times daily 30 minutes before meals and at bed time if required

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Kayem Pharma

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