DOXORUBICIN

Product: 
DOXORUBICIN
Formulary: 
Generic Formulary
Category: 
Neoplastics
Sub Group: 
ANTI NEOPLASTIC AGENTS
International Brand Name: 
Adriamycin PFS, Adriamycin RDF ,Rubex
Dosages: 
10 mg/50 mg
Unit of Packing: 
Vial
In treatment of: 
Treatment of Metastatic Breast Carcinoma
Adverse Effects: 
1. Nausea 2. Vomiting 3. Loss of appetite 4. Diarrhea 5. Difficulty in swallowing 6. Brittle hair 7. Skin irritation 8. Rash 9. Swelling 10. Pain 11. Redness 12. Peeling of the skin on the palms and soles of the feet. 13. Tarry stools 14. Cough 15. Chills 16. Facial swelling 17. Bruising or unusual bleeding 18. Weakness 19. Blood in urine or stools 20. Constipation 21. Anxiety 22. Burning 23. Itching eyes 24. Change in taste 25. Muscle ache 26. Swelling of eyes and eyelid 27. Trouble sleeping 28.Irreversible cardiomyopathy 29.Arrhythmia 30.Left ventricular failure
Contraiindication: 
1. Thrombocytopenia 2. Severe leucopenia 3. Myelosuppression 4. Previous treatment with antitumor agent or by radiotherapy 5. Cardiac disease
Special Precaution: 
1. Hyper sensitivity to other neoplastic drugs 2. Kidney diseases 3. Renal diseases 4. Recent Immunization
Interaction: 
Mercaptopurine: Hepatotoxicity of mercaptopurine enhanced leading to cholestasis. Cyclophosphamide: Exacerbation of cyclophosphamide induced hemorrhagic cystitis. Barbiturates: Increase the plasma clearance of doxorubicin. Digoxin: Decreased serum levels of digoxin. Streptozotocin: Increases toxicity of doxorubicin. Radiation: Radiation induced toxicity to myocardium, mucosa, skin and liver increased.
Servings: 
Intravenous- Adult- 60 to 75 mg/metre square single dose every 21 days 30mg/metre square daily every 3 days.

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