Generic Formulary
Infections & Infestations
Sub Group: 
International Brand Name: 
Vibromycin,Monodox, Microdox,Periostat, Vibrox,Doxylin,Atridox
100 MG
Unit of Packing: 
In treatment of: 
Treatment of susceptible infections;treatment of sensitive Gonococcala infections;treatment of Syphillis;treatment of relapsing fever and louse-brone typhus
Adverse Effects: 
1. Photo toxicity 2. Intracranial hypertension 3. Dysphagia 4. Nausea 5. Vomiting 6. Epigastric distress 7. Super infection 8. Skin rashes 9. Pericarditis 10. Neutropenia 11. Elevated liver enzymes 12. Discoloration of teeth 13. Esophageal ulceration 14. Glossitis 15. Thrombocytopenia 16. Retardation of bone growth
1. Hypersensitivity to the drug or other tetracyclines
Special Precaution: 
1.Renal impairment 2.Hepatic impairment 3.Sun exposure may leads to photo toxicity. 4.Alcohol uptake may decrease antibiotic effect.
Antacids (aluminium, calcium zinc, magnesium), Iron salts, Bismuth salts: Impair absorption of tetracyclines thus reducing its efficacy. Anticoagulants: Increase the hypothrombinemic effects of anticoagulants. Cimetidine: Decreases GI absorption leading to decreased efficacy of tetracyclines. Digoxin: Increased serum levels leading to digoxin toxicity. Methoxyflurane: Nephrotoxic effects of both increased. Oral contraceptives: Breakthrough bleeding, pregnancy due to decreased efficacy. Penicillins: Efficacy reduced. Food: Dairy products decrease efficacy of tetracyclines. Lab Tests: Bacteriosuppressive levels of Demeclocycline persist in both urine and blood for several days after cessation of therapy interfering with culture studies.
Adults: 0.2gm initial dose followed by 0.1gm once daily. In severe infections: 0.1gm 12 hourly up to 10 days. Malaria: 200 mg daily for at least 7 days after treatment with quinine. Malaria prophylaxis: Doxycycline 100 mg daily. Anthrax: 200 mg / day in 2 divided doses Acne: 100mg/day Or 50mg twice daily. Urethritis: 100 mg twice a day for 7 days Children (above 8 years of age): 3 to 5 mg/kg/day in two divided doses.

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