Infections & Infestations
International Brand Name:
Vibromycin,Monodox, Microdox,Periostat, Vibrox,Doxylin,Atridox
In treatment of:
Treatment of susceptible infections;treatment of sensitive Gonococcala infections;treatment of Syphillis;treatment of relapsing fever and louse-brone typhus
1. Photo toxicity
2. Intracranial hypertension
6. Epigastric distress
7. Super infection
8. Skin rashes
11. Elevated liver enzymes
12. Discoloration of teeth
13. Esophageal ulceration
16. Retardation of bone growth
1. Hypersensitivity to the drug or other tetracyclines
3.Sun exposure may leads to photo toxicity.
4.Alcohol uptake may decrease antibiotic effect.
Antacids (aluminium, calcium zinc, magnesium), Iron salts, Bismuth salts: Impair absorption of tetracyclines thus reducing its efficacy.
Anticoagulants: Increase the hypothrombinemic effects of anticoagulants.
Cimetidine: Decreases GI absorption leading to decreased efficacy of tetracyclines.
Digoxin: Increased serum levels leading to digoxin toxicity.
Methoxyflurane: Nephrotoxic effects of both increased.
Oral contraceptives: Breakthrough bleeding, pregnancy due to decreased efficacy.
Penicillins: Efficacy reduced.
Food: Dairy products decrease efficacy of tetracyclines.
Lab Tests: Bacteriosuppressive levels of Demeclocycline persist in both urine and blood for several days after cessation of therapy interfering with culture studies.
Adults: 0.2gm initial dose followed by 0.1gm once daily.
In severe infections: 0.1gm 12 hourly up to 10 days.
Malaria: 200 mg daily for at least 7 days after treatment with quinine.
Malaria prophylaxis: Doxycycline 100 mg daily.
Anthrax: 200 mg / day in 2 divided doses
Acne: 100mg/day Or 50mg twice daily.
Urethritis: 100 mg twice a day for 7 days
Children (above 8 years of age): 3 to 5 mg/kg/day in two divided doses.