DYDROGESTERONE

Product: 
DYDROGESTERONE
Formulary: 
Generic Formulary
Category: 
Genito Urinary System
Sub Group: 
DRUGS ACTING ON UTERUS
International Brand Name: 
Dusphoston
Dosages: 
10 MG
Unit of Packing: 
Tablets
In treatment of: 
Treatment of Endometriosis, mgt of recuurent miscarriage
Adverse Effects: 
1. Pulmonary embolism 2. Thromboembolism 3. Cerebrovascular accident 4. Breakthrough bleeding 5. Dysmenorrhea 6. Amenorrhea 7. Cervical erosions and abnormal secretions 8. Tenderness and enlargement of breast 9. Cholestatic jaundice 10. Depression 11. Alopecia 12. Somnolence 13. Rashes 14. Urticaria 15. Pruritus
Contraiindication: 
1. Hypersensitivity to the drug 2. Thromboembolic disorders 3. Cerebral apoplexy 4. Breast cancer 5. Hormone dependent carcinoma 6. Undiagnosed vaginal bleeding 7. Missed abortion 8. Hepatic impairment 9. Porphyria.
Special Precaution: 
1. Renal impairment 2. Liver diseases 3. Cardiovascular disorders 4. Diabetes mellitus 5. Seizures 6. Mental depression 7. Migraine 8. Asthma 9. Monitor blood pressure and for visual impairment
Interaction: 
Cyclosporin: Increased plasma cyclosporin concentration. Rifamycin: Metabolism accelerated by rifamycins.
Servings: 
Dosage: Oral: Endometriosis: 5 to 10mg twice daily to thrice daily; continuously or cyclically from 5th day to 21st day of menstrual cycle. Premenstrual syndrome: 5 to 10mg/day from 12th to 26th day of the menstrual cycle. Dysmenorrhea: 5 to10mg 12th hourly from 5th day to 25th day of menstrual cycle. Replacement therapy: 10mg/day for last 14 days of the menstrual cycle. Increases to twice daily if required. Habitual abortion: 10mg twice daily from 11th to 25th day of menstrual cycle and then continuously after conception during first half of pregnancy and reduces gradually. Infertility, Irregular cycles: 10mg 12th hourly from 11th to 25th day of menstrual cycle. Repeat as required. Dysfunctional uterine bleeding: 10mg 12th hourly together with an oestrogen for 5 to 7days. Prophylaxis: 10mg 12th hourly together with an oestrogen from 11th to 25th day of cycle.

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