International Brand Name:
Sompraz, Zoleri, Nexium, Lucen, Esopral; Axagon, Nexiam
2.Gastroesophageal reflux disease
4.NSAID associated ulceration
5.Duodenal ulcer related to H. pylori infection
2.Monitor gastric malignancy
Esomeprazole may potentially interfere with CYP2Cl9, the major esomeprazole metabolizing enzyme.
Esomeprazole may interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability (e.g., ketoconazole, iron salts and digoxin). Esomeprazole does not have any clinically significant interactions with phenytoin, warfarin, quinidine, clarithromycin or amoxycillin.
Gastro-oesophageal Reflux Disease (GORD): Healing of erosive oesophagitis: 20mg or 40mg once daily for 4 to 8 weeks.
Maintenance of healing of erosive esophagitis: 20mg once daily.
Symptomatic gastroesophageal reflux disease: 20mg once daily for 4 weeks.
H. pylori eradication to reduce the risk of duodenal ulcer recurrence
Esomeprazole: 40mg, once daily for 10 days along with Amoxycillin and Clarithromycin