Generic Formulary
Sub Group: 
International Brand Name: 
Etopophos,Toposar, VePesid
50 mg/ 100 mg
Unit of Packing: 
Capsule/ Vial
In treatment of: 
Treatment of Testicular Tumour,Lung Cancer,Tumours of the Brain,Git,Ovary and Thymus,acute Lymphomas
Adverse Effects: 
1. Nausea 2. Vomiting 3. Difficulty in breathing 4. Closing of the throat 5. Bone marrow suppression 6. Bruising or unusual bleeding 7. Tarry stools 8. Fever 9. Chills 10. Congestive heart failure 11. Diarrhea 12. Loss of appetite 13. Facial flushing 14. Darkening of skin and nails 15. Alopecia 16. Red urine 17. Leukemia 18. Hyperpyrexia 19. Amenorrhea 20. Anaphylaxis 21. Photosensitivity 22. Premature menopause 23. Thrombocytopenia 24. Neutropenia 25. Leucopenia 26. Conjunctivitis 27. Keratitis 28. Swelling of the lips, tongue and face 29. Peripheral neuropathy 30. Hypotension 31. Jaundice 32. Bronchospasm
1. Hypersensitivity to the drug 2. Severe bone marrow depression 3. Hepatic dysfunction
Special Precaution: 
1. Renal dysfunction 2. Treatment with cytotoxic drug 3. Recent radiation 4. Extravasations 5. Infection 6. Contraception 7. Monitor patient`s hepatic, renal and haematological functions regularly.
Warfarin: Prolongation of prothrombin time may occur. Other cytotoxic drugs: Synergism.
Adult- For small cell carcinoma of the lung- 70mg/metre square/day orally for 4 days OR 100mg/metre square /day orally for 5 days Repeat the treatment every 3-4 weeks For testicular carcinoma- 50-100mg/metre square intravenously daily for 5 days OR 100mg/metre square/day on days 1, 3, and 5 days Repeated the treatment every 4 weeks For Kaposi`s sarcoma- 150mg/metre square for 3 consecutive days every 4 weeks Repeat the dose as necessary

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