FELODIPINE

Product: 
FELODIPINE
Formulary: 
Generic Formulary
Category: 
Cardio Vascular System
Sub Group: 
ANTIANGINALS & CORONORY VASOLIDATORS
International Brand Name: 
Plendil
Dosages: 
2.5 MG/5 mg/10 mg
Unit of Packing: 
Tablets
In treatment of: 
Management of Angina Pectoris
Adverse Effects: 
1. Edema 2. Palpitation 3. Hypotension 4. Bradycardia 5. Syncope 6. Headache 7. Abdominal pain 8. Dizziness 9. Fatigue 10. Flushing 11. Tachycardia 12. Postural hypotension 13. Myocardial infarction 14. Elevated liver enzymes 15. Visual impairment 16. Impotence 17. Angina 18. Arrhythmia 19. Nausea 20. Leg cramps 21. Rashes 22. Gingival hyperplasia
Contraiindication: 
1. Acute myocardial infarction 2. Hypersensitivity to the drug 3. Unstable angina 4. Heart failure
Special Precaution: 
1. Congestive heart failure 2. Cardiovascular insufficiency 3. Hypotension 4. Left ventricular outflow obstruction. 5. Hepatic impairment 6. Slowly withdraw the drug with caution 7. Use cautiously in women in reproductive age group 8. Use cautiously along with other antihypertensive drugs 9. The drug may leads to hypotension, tachycardia, and myocardial ischaemia.
Interaction: 
Histamine H2 antagonists: May increase bioavailability by 50%. Digitalis glycosides: Serum digoxin levels may be increased upto 40% approx. Beta blockers: Concomitant use may result in increase adverse effects due to depressant effect on myocardial contractility. Phenytoin, Carbamapezine, Barbiturates: Plasma levels of felodipine may be reduced. Food: Bioavailability not affected by food, however it is increased more than two-fold when taken with doubly concentrated grape fruit juice, compared to water or orange juice.
Servings: 
Starts with 5mg once daily. Increase the dosage up to 10mg once daily at 2 week intervals depending up on the patient`s response. Maximum dose: 20mg

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