Filgrastim

Product: 
Filgrastim
Formalary: 
Specialty Formalary
Category: 
Oncology
Trade Name: 
Neupogen;Grastin;Nugraf;Shilgrast,;Neukine;Religras;Zarzio
Packing: 
Vial
Potency: 
30mcg, 48mcg
In Treatment of: 
Filgrastim is used to treat neutropenia[2] (a low number of neutrophils), stimulating the bone marrow to increase production of neutrophils. Causes of neutropenia include chemotherapy and bone marrow transplantation. Filgrastim is also used to increase the number of hematopoietic stem cells in the blood before collection by leukapheresis for use in hematopoietic stem cell transplantation
Adverse Effects: 
You will probably not have most of the following side effects, but if you have any talk to your doctor or nurse. They can help you understand the side effects and cope with them. Common • None Less common • Bone and muscle pain • Abnormal blood tests which suggest that the drug is affecting the liver (Your doctor will discuss the importance of this finding, if any.) Rare • Injection site reaction (redness, pain, or swelling) • Allergic reaction* • Spleen enlargement or rupture* • Trouble breathing or coughing up blood* • Death due to spleen rupture, bleeding, sickle cell crisis (in people with sickle cell anaemia
Contraindication: 
It is contraindicated in patients with known hypersensitivity to E coli-derived proteins‚ Filgrastim‚ or any component of the product.
Special Precaution: 
Patients with acute myeloid leukemia (AML) or chronic myelogenous leukemia (CML) should not get this drug, as it could potentially spur the growth of these types of cancer cells. This drug is generally not given within 24 hours of chemotherapy treatments. Your doctor will obtain blood tests to find out how you respond to the drug. Your doctor will adjust your dose based on your test results. Keep all your appointments for doctor visits and blood tests. Even though this drug is given to help you fight infections, it cannot prevent all infections. Call your doctor if you notice signs of infection such as fever (100.5° or higher), chills, pain when passing urine, a new cough, or bringing up sputum. In a few people, this drug has caused severe lung problems, trouble breathing (acute respiratory distress syndrome), or coughing up blood. Let your doctor know right away of any shortness of breath you notice. In rare cases, this drug can cause allergic reactions, especially with the first few treatments. Mild reactions may consist of fever, chills, skin itching, or feeling flushed. More serious reactions happen rarely, but can be dangerous. Symptoms can include feeling lightheaded or dizzy (due to low blood pressure),fast pulse, chest tightness, shortness of breath, back pain, or swelling of the face, eyes, tongue, or throat. Tell your doctor or nurse right away if you notice any of these symptoms during or after being given the drug. In rare cases, people getting this drug have had their spleen grow very large or even rupture, which can cause death. Let your doctor know right away if you begin to have pain or swelling on your left side under your rib cage or if you notice pain in your left shoulder area. If you are having surgery, including dental surgery, tell your surgeon or dentist that you are using figrastim. If you plan to have a bone imaging study, be sure the doctor and technician know you are using this drug. Filgrastim may affect the imaging results. The drug has also been known to cause osteoporosis in children.
Interaction: 
Drug interactions between Filgrastim and other drugs have not been fully evaluated. Drugs which may potentiate the release of neutrophils‚ such as lithium‚ should be used with caution. Increased hematopoietic activity of the bone marrow in response to growth factor therapy has been associated with transient positive bone imaging changes. This should be considered when interpreting bone-imaging results.
Dosages: 
The recommended child and adult dose of filgrastim is based on body weight and varies depending on the circumstances of its use. Filgrastim is given by subcutaneous (under the skin) or intravenous (into a vein) injection. Your dose may be adjusted depending on your response to this medication and therapy is usually continued until neutrophil counts reach an acceptable level. For some conditions, filgrastim will be needed indefinitely. Filgrastim is usually given under medical supervision. If you are giving filgrastim to yourself, your doctor or health care professional will instruct you on how to use filgrastim properly. It is important to use this medication exactly as prescribed by your doctor. Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor. This medication should be stored in the refrigerator, but do not allow it to freeze. Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

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