Generic Formulary
Cardio Vascular System
Sub Group: 
International Brand Name: 
40 MG/100 mg
Unit of Packing: 
In treatment of: 
Treatment of Oedema associated w/ heart failure
Adverse Effects: 
1. Dizziness 2. Headache 3. Diarrhoea 4. Anorexia 5. Nausea 6. Polyurea 7. Vomiting 8. Constipation 9. Frequent urination 10. Nocturea
1. Hypo natraemia 2. Hypo kalaemia 3. Hypo volaemia 4. Hypotension 5. Hepatic coma 6. Hypersensitivity to the drug 7. Anuric renal failure
Special Precaution: 
1. Hepatic impairment 2. Renal impairment 3. Gout 4. Diabetes mellitus 5. Hypersensitivity to Sulfonamides 6. Fluid and electrolyte imbalance 7. Long term purgatives 8. Hepatic cirrhosis 9. Chronic Diarrhoea and dehydration.
Anticoagulants: Activity of anticoagulants may be enhanced. Aminoglycoside antibiotics: Frusemide increases potential for ototoxicity. Cisplatin: Frusemide increases potential for ototoxicity. Digitalis glycosides: Diuretics induced potassium loss may precipitate digitalis toxicity, increased frequency of cardiac arrhythmias. NSAIDs: Effect of frusemide reduced. Lithium: Therapeutic and toxic effects of lithium increased. Metolazone: Profound diuresis and greater than predicted electrolyte loss related to the ability of metolazone to block proximal tubular sodium reabsorption useful in patients refractory to frusemide.
Oral: Oedema: 40mg in the morning. Increased if required; based on patient`s response up to 80mg. Maintenance dosage: 20 to 40mg daily or on alternate days. Maximum dose: 600mg/day. Children: 3mg/kg/day. I.V.: Adult: 20 to 50mg as slow I.V. or I.M. injection. Increased by 20mg every 2hours. Higher I.V. doses must be infused Children: 0.5 to 1.5mg/kg/day.

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