GLICLAZIDE

Product: 
GLICLAZIDE
Formulary: 
Generic Formulary
Category: 
Diabetes
Sub Group: 
ORAL ANTIDIABETICS & RELATED DRUGS
International Brand Name: 
Diamicron
Dosages: 
30 MG/60mg/80mg
Unit of Packing: 
Tablets
In treatment of: 
treatment of type Diabetes Mellitus
Adverse Effects: 
1. Hypoglycemia 2. Nausea 3. Vomiting 4. Diarrhoea 5. Constipation 6. Headache 7. Paresthesia 8. Hypersensitivity reactions 9. Rashes 10. Photosensitivity 11. Purpura 12. Transient leucopenia 13. Agranulocytosis 14. Blood dyscrasias
Contraiindication: 
1. Hypersensitivity to the drug 2. Diabetic ketoacidosis 3. Diabetic coma 4. Renal impairment 5. Hepatic impairment
Special Precaution: 
1. Malnourished and deliberate individuals 2. Periods of metabolic stress 3. Hepatic diseases 4. Renal diseases
Interaction: 
Hypoglycaemic effect of gliclazide is enhanced by: Anticoagulants, Androgens, Chloramphenicol, Clofibrate, Fenfluramine, Fluconazole, Gemfibrozil, Histamine H2 antagonists, Magnesium Salts, Methyldopa, MAOIs, Phenylbutazone, Probenecid, Salicylates, Sulfinpyrazone, Sulfonamides, TCAs, & Urinary acidifiers. Hypoglycemic effect of gliclazide inhibited by the following drugs: b-blockers, Cholestyramine, Diazoxide, Hydantoins, Rifampicin, Thiazide diuretics & Urinary alkalisers. Charcoal: Reduces the absorption of gliclazide thus reducing its efficacy or toxicity. Digitalis glycosides: Co-administration results in increased digitalis serum levels.
Servings: 
80mg twice daily. Adjust the dosage up to 160mg twice daily based on patient`s response if required.

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